Effect of pregnancy followed by lactation on miRNAs modulation of maternal pancreatic islets

• Grant number: 17/11138-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2017
• End date: July 31, 2019
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal Investigator: Licio Augusto Velloso
• Grantee: Julia Modesto Vicente
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID

Abstract

A series of studies show that duration of breastfeeding has an inverse relationship with the risk of mothers developing Type 2 diabetes mellitus (T2DM). Despite this, the mechanism by which breastfeeding duration affects late maternal metabolism is unknown yet. Recently, it has been shown that the differential expression of miRNAs may be the basis of long-term functional modifications. Ongoing studies from our laboratory show that mice that become pregnant and breastfeed retain high insulin secretory capacity for pancreatic islets. This phenotypic change is accompanied by increased glucose tolerance and it lasts for two months after weaning. The present project aims to track the miRNAs differentially expressed in pancreatic islets that may potentially be associated with this adaptation. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VICENTE, JULIA MODESTO; SANTOS-SILVA, JUNIA CAROLINA; TEIXEIRA, CAIO JORDAO; DE SOUZA, DAILSON NOGUEIRA; VETTORAZZI, JEAN FRANCIESCO; FURTUOSO, FABIOLA SALES; ADABO, ISABEL GOUVEIA; SATO, FABIO TAKEO; RAMIREZ VINOLO, MARCO AURELIO; CARNEIRO, EVERARDO MAGALHAES; et al. Long-term increase of insulin secretion in mice subjected to pregnancy and lactation. ENDOCRINE CONNECTIONS, v. 9, n. 4, p. 299-308, APR 2020. (13/07607-8, 15/12680-1, 17/11138-4)

VICENTE, JULIA MODESTO; SANTOS-SILVA, JUNIA CAROLINA; TEIXEIRA, CAIO JORDAO; DE SOUZA, DAILSON NOGUEIRA; VETTORAZZI, JEAN FRANCIESCO; FURTUOSO, FABIOLA SALES; ADABO, ISABEL GOUVEIA; SATO, FABIO TAKEO; RAMIREZ VINOLO, MARCO AURELIO; CARNEIRO, EVERARDO MAGALHAES; et al. Long-term increase of insulin secretion in mice subjected to pregnancy and lactation. ENDOCRINE CONNECTIONS, v. 9, n. 4, p. 10-pg., 2020-04-01. (15/12680-1, 13/07607-8, 17/11138-4)