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Investigation of peripheral and central action of angiotensin-(1-7)on urinary bladder regulation in female Wistar rats

Grant number: 17/07161-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2017
Effective date (End): June 30, 2019
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Monica Akemi Sato
Grantee:Gustavo Bertollini Lamy
Home Institution: Centro Universitário Saúde ABC. Fundação do ABC. Santo André , SP, Brazil


The voiding dysfunctions affect men and women, as well as children. Throughout the world, the highest percentage of cases occurs in women. These micturition dysfunctions may occur due to changes in detrusor muscle control, sphincterian or both and may be due to injury or degeneration of the central and / or peripheral nervous system, as well as of peripheral organs. The maintenance of excretion and urinary storage depends on reflex mechanisms, and the onset of urination is influenced by the Pontine Micturation Center (PMC), while urine storage is modulated by the Pontine Urinary Storage Center (PUSC), which is located ventrolaterally to PMC. Studies on the pseudorabies virus injection into the urinary bladder wall showed that, after a long period of incubation, infected neurons are found in the lumbosacral spinal cord, raphe nucleus, reticular formation, pontine micturition center (PMC), locus coeruleus, red nucleus, hypothalamus, preoptic area and cortical areas. These evidence indicate that a multisynaptic neuronal circuit is involved in the efferent control of the urinary bladder. The discovery of angiotensin- (1-7) (Ang 1-7) formed by an ACE-independent pathway, which was able to bind to the MAS receptor and have actions in vitro and in vivo, allowed its recognition as a biologically active peptide Of the Renin-Angiotensin System. Using the immunofluorescence technique in the central nervous system of Wistar rats, the presence of the MAS receptor was demonstrated in areas related to the cardiovascular system in the medulla oblongata and also in the forebrain, as in the supraoptic nucleus and also in the lateral preoptic area. Although Ang- (1-7) actions have been demonstrated in some hypothalamic areas, there is still no evidence whether Ang 1-7 could act in forebrain areas such as the lateral preoptic area to modulate urinary bladder regulation. Thus, the present study will evaluate the hypothesis that Ang 1-7 could act in the lateral preoptic area to promote changes in urinary bladder control. In addition, it will be investigated if Ang 1-7 could also act directly on the urinary bladder affecting its regulation. (AU)

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