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Effects of sleep fragmentation on Th1/Th2 paradigm on a murine model of leishmaniasis immune activation

Grant number: 17/13999-7
Support type:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): September 01, 2017
Effective date (End): August 14, 2018
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Monica Levy Andersen
Grantee:Rachel Gimenes Rodrigues Albuquerque
Supervisor abroad: Cord Sunderkoetter
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Research place: University of Munster, Germany  
Associated to the scholarship:14/27329-5 - Analysis of sleep pattern and cytokine secretion in leprosy patients, BP.DD


The first experiments that demonstrated the importance of the balance between T helper 1 (Th1) and T helper 2 (Th2) were conducted in experimental models of murine leishmaniasis. After the inoculation of a higher number of Leishmania major parasites, some mice strains proved to be resistant, as observed in C57BL/6 strain, and others develop lesions and even systemic disease, as in BALB/c strain. Most of studies indicate that there is a genetic background that drives to interleukin-12 and interferon-³ production and then to a Th1 response (resistance), or interleukin-4 secretion and consequently Th2 response (susceptibility). In addition to genetics, other aspects, such as dietary and senescence are considered important. One factor that exhibits a bidirectional relationship with the immune system is sleep. Although the role of sleep on the murine model of leishmaniasis is unknown, a wide range of studies describe the importance of pro- and anti-inflammatory cytokines in the regulation of sleep wake-cycle, alterations on sleep pattern during infections and the negative impact of sleep deprivation on immune cells. Considering that a consolidated sleep is fundamental to guarantee the immune system well-function and homeostasis, this study seeks to evaluate the effects of sleep fragmentation in Th1/Th2 paradigm using a murine model of leishmaniasis. We expect to clarify which parameters are affected by a fragmented sleep after immunological challenge, such as infections and active immunizations processes. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RACHEL GIMENES ALBUQUERQUE; JANE TOMIMORI; LUCILE MARIA FLOETER-WINTER; SERGIO TUFIK; MONICA LEVY ANDERSEN. Clinical management of leprosy patients during the yellow fever outbreak in Brazil. Brazilian Journal of Infectious Diseases, v. 22, n. 6, p. 503-504, Nov. 2018. Web of Science Citations: 0.

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