| Grant number: | 17/02748-3 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | September 01, 2017 |
| End date: | July 31, 2018 |
| Field of knowledge: | Physical Sciences and Mathematics - Computer Science - Theory of Computation |
| Principal Investigator: | João Meidanis |
| Grantee: | João Paulo Pereira Zanetti |
| Host Institution: | Instituto de Computação (IC). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
Abstract Genome comparison can be made in several ways. In many applications, reducing the differences between two genomes to a single real number expressing their distance is important. In recent years, a measure called DCJ distance, which combines biological appeal with computational efficiency, has been heavily used. Another measure called algebraic distance, related to the rank distance in matrices, posseses similar characteristics but has been less explored.In this project, we intend to study the behaviour of the rank distance in situations already examined under the DCJ distance, including the determination of all optimum rearrangement scenarios, assessment of the distance's performance in phylogenetic reconstruction, and addition of insetions, deletions, and duplications.To overcome the challenges we face in this project, we rely on advancing the matrix-based theory of genome rearrangements, in which we expect the rank distance will exhibit algebraic properties not shared by the DCJ distance. | |
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