Development of bio-inspired PLA/bioglass scaffolds via 3D printed

• Grant number: 17/11366-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: September 01, 2017
• End date: August 18, 2020
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Luiz Antonio Pessan
• Grantee: Eduardo Henrique Backes
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated scholarship(s): 18/13625-2 - Evaluation of the mechanical properties and bioactivity of bio-inspired PLA/bioactive fillers scaffolds produced via 3D printing, BE.EP.DR

Abstract

Over the last years orthopedic procedures for bone repairs due to trauma, new implants, as well as new surgical procedures, have been developed. One of the most prominent alternatives is the development of scaffolds. These may be made of metals, ceramics or polymers and should mimic the natural extracellular matrix of bone (architecture, biochemistry and mechanical properties), allowing cell binding, proliferation and differentiation. The metal scaffolds present problems with the release of metallic ions, whereas the ceramic scaffolds are fragile and difficult to conformation and polymer scaffolds have insufficient mechanical properties. One way to produce scaffolds with adequate mechanical properties and bioactive behavior, is to produce PLA/bioglass composites, which will be developed in this project, joining the characteristics of biocompatibility and biodegradability of PLA and osteoinduction of bioglass. Conventional techniques for the production of polymer/bioglass composites employ solvents and originate morphology with pore size distribution. In this project the manufacture of PLA/bioglass scaffolds will be performed via additive manufacturing technique, 3D printing, for the production of bioactive scaffolds, with controlled morphology (pore sizes that mimic the bone structure) and which present mechanical and permeability properties adequate for application in bone regeneration. (AU)

Scientific publications

(10)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

BACKES, EDUARDO HENRIQUE; PIRES, LAIS DE NOBILE; BEATRICE, CESAR AUGUSTO GONCALVES; COSTA, LIDIANE CRISTINA; PASSADOR, FABIO ROBERTO; PESSAN, LUIZ ANTONIO. Fabrication of Biocompatible Composites of Poly(lactic acid)/Hydroxyapatite Envisioning Medical Applications. POLYMER ENGINEERING AND SCIENCE, v. 60, n. 3, JAN 2020. (16/19978-9, 17/11366-7, 17/09609-9)

BACKES, EDUARDO H.; FERNANDES, EMANUEL M.; DIOGO, GABRIELA S.; MARQUES, CATARINA F.; SILVA, TIAGO H.; COSTA, LIDIANE C.; PASSADOR, FABIO R.; REIS, RUI L.; PESSAN, LUIZ A.. Engineering 3D printed bioactive composite scaffolds based on the combination of aliphatic polyester and calcium phosphates for bone tissue regeneration. Materials Science & Engineering C-Materials for Biological Applications, v. 122, MAR 2021. (17/11366-7, 11/21313-1, 18/13625-2, 17/09609-9)

GONCALVES BEATRICE, CESAR AUGUSTO; BORIOLO SHIMOMURA, KAWANY MUNIQUE; BACKES, EDUARDO HENRIQUE; HARB, SAMARAH VARGAS; COSTA, LIDIANE CRISTINA; PASSADOR, FABIO ROBERTO; PESSAN, LUIZ ANTONIO. Engineering printable composites of poly (epsilon-polycaprolactone) / beta-tricalcium phosphate for biomedical applications. Polymer Composites, v. 42, n. 3, DEC 2020. (17/11366-7, 18/26060-3, 17/09609-9, 18/14151-4, 11/21313-1)

BACKES, EDUARDO HENRIQUE; BEATRICE, CESAR AUGUSTO GONCALVES; SHIMOMURA, KAWANY MUNIQUE BORIOLO; HARB, SAMARAH VARGAS; PACHANE, BIANCA CRUZ; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO; COSTA, LIDIANE CRISTINA; PASSADOR, FABIO ROBERTO; PESSAN, LUIZ ANTONIO. Development of poly(epsilon-polycaprolactone)/hydroxyapatite composites for bone tissue regeneration. Journal of Materials Research, v. 36, n. 15, SI, AUG 2021. (11/21313-1, 17/09609-9, 18/14151-4, 17/11366-7, 18/26060-3)

BACKES, EDUARDO HENRIQUE; HARB, SAMARAH VARGAS; PINTO, LEONARDO ALVES; DE MOURA, NAYARA KOBA; DE MELO MORGADO, GUILHERME FERREIRA; MARINI, JULIANO; PASSADOR, FABIO ROBERTO; PESSAN, LUIZ ANTONIO. Thermoplastic polyurethanes: synthesis, fabrication techniques, blends, composites, and applications. Journal of Materials Science, v. 59, n. 4, p. 30-pg., 2024-01-18. (19/27415-2, 17/11366-7, 18/26060-3, 20/12501-8)

HARB, SAMARAH V.; KOLANTHAI, ELAYARAJA; BACKES, EDUARDO H.; BEATRICE, CESAR A. G.; PINTO, LEONARDO A.; NUNES, ANA CAROLINA C.; SELISTRE-DE-ARAUJO, HELOISA S.; COSTA, LIDIANE C.; SEAL, SUDIPTA; PESSAN, LUIZ ANTONIO. Effect of Silicon Dioxide and Magnesium Oxide on the Printability, Degradability, Mechanical Strength and Bioactivity of 3D Printed Poly (Lactic Acid)-Tricalcium Phosphate Composite Scaffolds. TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v. 21, n. 2, p. 20-pg., 2023-10-19. (18/26060-3, 17/09609-9, 19/27415-2, 17/11366-7, 21/11538-8)

BACKES, EDUARDO HENRIQUE; PIRES, LAIS DE NOBILE; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO; COSTA, LIDIANE CRISTINA; PASSADOR, FABIO ROBERTO; PESSAN, LUIZ ANTONIO. Development and characterization of printablePLA/beta-TCPbioactive composites for bone tissue applications. Journal of Applied Polymer Science, v. 138, n. 5, AUG 2020. (16/19978-9, 19/11437-7, 17/11366-7, 17/09609-9, 11/21313-1)

BACKES, EDUARDO HENRIQUE; HARB, SAMARAH VARGAS; BEATRICE, CESAR AUGUSTO GONCALVES; SHIMOMURA, KAWANY MUNIQUE BORIOLO; PASSADOR, FABIO ROBERTO; COSTA, LIDIANE CRISTINA; PESSAN, LUIZ ANTONIO. Polycaprolactone usage in additive manufacturing strategies for tissue engineering applications: A review. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, DEC 2021. (18/14151-4, 17/11366-7, 18/26060-3, 17/09609-9)

HARB, SAMARAH, V; KOLANTHAI, ELAYARAJA; PINTO, LEONARDO A.; BEATRICE, CESAR A. G.; BEZERRA, EWERTON DE O. T.; BACKES, EDUARDO H.; COSTA, LIDIANE C.; SEAL, SUDIPTA; PESSAN, LUIZ A.. Additive manufacturing of bioactive and biodegradable poly (lactic acid)-tricalcium phosphate scaffolds modified with zinc oxide for guided bone tissue repair. Biomedical Materials, v. 19, n. 5, p. 16-pg., 2024-09-01. (17/09609-9, 19/27415-2, 17/11366-7, 18/26060-3)

MAREGA, FELIPPE MIGLIATO; KLOK, LARISSA ALINE; STEFFEN, TERESA TROMM; CUNHA, DANIEL A. L. V.; HARB, SAMARAH V.; KOLANTHAI, ELAYARAJA; SEAL, SUDIPTA; BECKER, DANIELA; PESSAN, LUIZ ANTONIO; COSTA, LIDIANE CRISTINA. Development of surface-treated poly(lactic acid)/zinc oxide biocomposites for 3D printing in bone tissue engineering. Journal of Applied Polymer Science, v. 141, n. 38, p. 16-pg., 2024-07-08. (18/26060-3, 17/09609-9, 19/27415-2, 17/11366-7, 21/11538-8, 22/03157-7)