Identification of polymorphisms related to HTLV-1 associated myelopathy / tropical spastic paraparesis (HAM / TSP)

• Grant number: 16/03025-2
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: October 01, 2017
• End date: December 31, 2021
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Jorge Simao do Rosario Casseb
• Grantee: Tatiane Assone Casseb
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 19/18522-0 - An integrated genomic, transcriptomic and metabolomic analysis of (immuno)pathogenic mechanisms leading to HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), BE.EP.PD

Abstract

Introduction: HTLV-1 was described in 1980, and has been mainly related to the causative agent of ATL and HAM / TSP, in addition to other inflammatory diseases. It is estimated that 15 to 25 million people worldwide are infected with HTLV-1. However, most of them remain asymptomatic. Immune and genetic factors of the host are related to the development of HAM/TSP, but there are no studies that evaluate the influence of these aspects and the association with the development of myelopathy. Objective: To analyze whether there is an association between some genetic polymorphisms related to the immune response in patients infected with HTLV-1 with HAM / TSP. Material and Methods: The volunteers will be recruited from the HTLV outpatient clinic of the "Emílio Ribas" Institute of Infectious Diseases (IIER). A total of 600 volunteers will be recruited for this study, and divided into three groups (200 asymptomatic, 200 HAM / TSP and 200 non-HTLV-1 infected relatives). Genetic polymorphism assays, HTLV-1 proviral load and T cell lymphoproliferation will be performed on all samples collected. The data will be treated using descriptive, univariate and multivariate statistics. Conclusion: These data may contribute to the understanding of the pathogenesis for the development of HAM / TSP and its clinical management.

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARCUSSO, ROSA MARIA N.; VAN WEYENBERGH, JOHAN; LUISI DE MOURA, JOAO VICTOR; DAHY, FLAVIA ESPER; BRASIL MATOS, ALINE DE MOURA; HAZIOT, MICHEL E. J.; VIDAL, JOSE E.; FONSECA, LUIZ AUGUSTO M.; SMID, JERUSA; ASSONE, TATIANE; et al. Dichotomy in Fatal Outcomes in a Large Cohort of People Living with HTLV-1 in Sao Paulo, Brazil. PATHOGENS, v. 9, n. 1, JAN 2020. (18/07239-2, 17/08320-5, 16/03025-2)

ROSADAS, CAROLINA; MENEZES, MARIA LUIZA B.; GALVAO-CASTRO, BERNARDO; ASSONE, TATIANE; MIRANDA, ANGELICA E.; ARAGON, MAYRA G.; CATERINO-DE-ARAUJO, ADELE; TAYLOR, GRAHAM P.; ISHAK, RICARDO. Blocking HTLV-1/2 silent transmission in Brazil: Current public health policies and proposal for additional strategies. PLoS Neglected Tropical Diseases, v. 15, n. 9, SEP 2021. (16/03025-2)

DA SILVA PRATES, GABRIELA; MALTA, FERNANDA M.; DE TOLEDO GONCALVES, FERNANDA; MONTEIRO, MARIANA A.; FONSECA, LUIZ AUGUSTO M.; R. VEIGA, ANA PAULA; M. C. MAGRI, MARCELLO; DUARTE, ALBERTO J. S.; CASSEB, JORGE; ASSONE, TATIANE; et al. AIDS incidence and survival in a hospital-based cohort of HIV-positive patients from Sao Paulo, Brazil: The role of IFN-lambda 4 polymorphisms. Journal of Medical Virology, v. 93, n. 6, p. 3601-3606, JUN 2021. (16/03025-2, 19/18522-0, 17/08320-5, 18/07239-2)

ORLETTI, MARIA P. S.; ASSONE, TATIANE; SARNAGLIA, GLENIA DAROS; MARTINS, MARINA LOBATO; ROSADAS, CAROLINA; CASSEB, JORGE; TAYLOR, GRAHAM; FERREIRA-FILHO, JOAQUIM B.; PEREIRA, FAUSTO E. L.; MIRANDA, ANGELICA ESPINOSA. Prevalence of infection by human T Cell lymphotropic viruses (HTLV-1/2) in adult population in Vitoria-ES. Brazilian Journal of Infectious Diseases, v. 25, n. 5, SEP-OCT 2021. (16/03025-2)

PRATES, GABRIELA; ASSONE, TATIANE; CORRAL, MARCELO; BALDASSIN, MAIRA P. M.; MITIKO, TATIANE; SALES, FLAVIA C. SILVA; HAZIOT, MICHEL E.; SMID, JERUSA; FONSECA, LUIZ A. M.; GONCALVES, FERNANDA DE TOLEDO; et al. Prognosis Markers for Monitoring HTLV-1 Neurologic Disease. NEUROLOGY-CLINICAL PRACTICE, v. 11, n. 2, p. 134-140, APR 2021. (16/03025-2)

PAIVA, ARTHUR M.; ASSONE, TATIANE; HAZIOT, MICHEL E. J.; SMID, JERUSA; FONSECA, LUIZ AUGUSTO M.; LUIZ, OLINDA DO CARMO; PENALVA DE OLIVEIRA, AUGUSTO CESAR; CASSEB, JORGE. Risk factors associated with HTLV-1 vertical transmission in Brazil: longer breastfeeding, higher maternal proviral load and previous HTLV-l-infected offspring. SCIENTIFIC REPORTS, v. 8, MAY 17 2018. (14/22827-7, 16/03025-2)

ASSONE, TATIANE; MENEZES, SORAYA MARIA; GONCALVES, FERNANDA DE TOLEDO; FOLGOSI, VICTOR ANGELO; PRATES, GABRIELA DA SILVA; DIERCKX, TIM; BRAZ, MARCOS; SMID, JERUSA; HAZIOT, MICHEL E.; MARCUSSO, ROSA M. N.; et al. Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation. JOURNAL OF NEUROINFLAMMATION, v. 19, n. 1, p. 15-pg., 2022-12-08. (17/08320-5, 16/03025-2, 18/07239-2)