Evaluation of ruthenium-phtalocyanine complex conjugated with lanthanide dopped silica theranostic effect over neoplastic cells

• Grant number: 17/04099-2
• Support Opportunities: Scholarships in Brazil - Master
• Start date: September 01, 2017
• End date: April 30, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Roberto Santana da Silva
• Grantee: Alexia Marques Silva
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The ruthenium nitrosyl complexes had shown different biological activities, among them the antitumoral properties. Therefore, the aim of this work is the development of ruthenium-phtalocyanine conjugated with lanthanide dopped silica nanoparticles, once the nanoparticles absorb light in x-ray region and emit light in therapeutic window region, causing the nitric oxide release and allowing the application of those complexes in treatment of inner cancer types, as lung cancer. Besides the cytotoxic and structural studies over this system, the production of drug delivery system will also be done, in attempt to keep the silica-complex properties until it reach the target cell in biological medium. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Alexia Marques. Ruthenium-phthalocyanine complexes conjugated to aminofunctionalized surface of Er3+ and Yb3+ doped yttrium oxide upconverting nanoparticles. Chemical, photochemical and photobiological characterization. 2019. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.