The role of a Peroxisome Proliferator-Activated Receptor Gamma agonist (PPAR-³) in the recruitment of inducible brown adipose tissue in humans by stabilizing proteins involved in the transcriptional cascade of adipogenesis

• Grant number: 17/06245-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2017
• End date: January 31, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Licio Augusto Velloso
• Grantee: Gabriela Margato Pascon
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID

Abstract

In recent years, the presence of brown adipose tissue (BAT) has been described in humans, a different type of fat capable of increasing energy expenditure rather than accumulating fat, leading to discussion about whether itsRecruitment and increased activity would be a therapeutic alternative for the treatment of obesity and diabetes. Among the therapeutic alternatives that lead to increased BAT activity, there is the use of PPAR³ agonists, which in cellular models and in mice induce a BAT gene program in white adipocytes, enhancing energy expenditure. Here, we propose in humans to evaluate the role of aPPAR³ agonist in the recruitment of BAT in subcutaneous white adipose tissue and in BAT activity, in parallel with its ability to promote thermogenesis induced by cold. We also propose a mechanistic investigation into fabricHuman adipose on the role of stability of transcriptional factors involved in adipogenesis. (AU)