Epigenetic regulation of PGC-1a expression in the liver of offspring subjected to ...
| Grant number: | 17/06245-6 |
| Support type: | Scholarships in Brazil - Scientific Initiation |
| Effective date (Start): | September 01, 2017 |
| Effective date (End): | January 31, 2018 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal Investigator: | Licio Augusto Velloso |
| Grantee: | Gabriela Margato Pascon |
| Home Institution: | Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
| Associated research grant: | 13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID |
Abstract In recent years, the presence of brown adipose tissue (BAT) has been described in humans, a different type of fat capable of increasing energy expenditure rather than accumulating fat, leading to discussion about whether itsRecruitment and increased activity would be a therapeutic alternative for the treatment of obesity and diabetes. Among the therapeutic alternatives that lead to increased BAT activity, there is the use of PPAR³ agonists, which in cellular models and in mice induce a BAT gene program in white adipocytes, enhancing energy expenditure. Here, we propose in humans to evaluate the role of aPPAR³ agonist in the recruitment of BAT in subcutaneous white adipose tissue and in BAT activity, in parallel with its ability to promote thermogenesis induced by cold. We also propose a mechanistic investigation into fabricHuman adipose on the role of stability of transcriptional factors involved in adipogenesis. (AU) | |