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Use of high-content screening to evaluate drug leishmanicidal activity in macrophages

Grant number: 17/19040-3
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): October 01, 2017
Effective date (End): February 28, 2022
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Dario Simões Zamboni
Grantee:Leticia de Almeida
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/08216-2 - CRID - Center for Research in Inflammatory Diseases, AP.CEPID


Leishmania amazonensis is one of the Leishmania species that cause leishmaniasis in Brazil, an endemic disease present in several countries. The disease can cause death and is considered by the World Health Organization a neglected tropical disease. Currently available treatments are expensive, long-lasting, and offer cardiac, hepatic and renal risks to those infected. In some cases, treatment is not effective in controlling infection, and selection of drug-resistant parasites is a major concern. Thus, this project aims to identify possible drugs approved for use in humans that may contribute to the control of L. amazonensis replication in macrophages. The development of this work will help in the future development of effective therapeutic strategies for the treatment of leishmaniasis caused by several species of Leishmania.

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