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Unraveling genetic sensitivity of Nellore cattle to environmental variation

Grant number: 17/18415-3
Support type:Scholarships abroad - Research
Effective date (Start): January 15, 2018
Effective date (End): January 14, 2019
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal Investigator:Roberto Carvalheiro
Grantee:Roberto Carvalheiro
Host: Stephen Moore
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Local de pesquisa : University of Queensland, Brisbane (UQ), Australia  

Abstract

The main objective of this project is to unravel the genetic sensitivity of Nellore cattle to environmental variation. For this, phenotypic and genotypic data from Nellore cattle raised under diverse environmental conditions will be studied. Sensitivity to environmental variation will be assessed for several growth and reproduction traits. Data from commercial breeding programs will be used, encompassing phenotypic records from approximately one million calves and 300,000 heifers/cows, and genotypic information from roughly 15,000 animals which were genotyped with the Illumina Bovine HD (HD) chip or with a lower density chip and had their genotypes imputed to the HD. For each trait, reaction norm models will be applied to estimate the response of each animal to environmental change. The estimated random regression coefficients of each animal will be used as pseudo-phenotypes on genome-wide association (GWA) analyses to identify candidate regions and genes associated to sensitivity to environmental variation. A meta-analysis of the GWA results will also be performed aiming to identify possible pleiotropic regions affecting sensitivity. Finally, cross-validation studies will be carried out to assess the accuracy of genomic predictions of sensitivity to environmental variation, under different methods. The results of the present study are expected to provide support for the development of strategies and tools to select Nellore cattle more able to cope with environmental variation, aiming to increase efficiency of beef production.

News published in Agência FAPESP Newsletter about the scholarship:
Study identifies genes potentially associated with heat- and drought-resistant cattle 
Articles published in other media outlets (27 total):
More itemsLess items
Revista Pecuária Brasil: Os genes da rusticidade (01/Nov/2019)
The Dairy Site (EUA): Brazilian Study Identifies Genes Potentially Associated with Heat- and Drought-resistant Cattle (16/Oct/2019)
The Cattle Site (Reino Unido): Brazilian Study Identifies Genes Potentially Associated with Heat- and Drought-resistant Cattle (16/Oct/2019)
The Beef Site (Reino Unido): Brazilian Study Identifies Genes Potentially Associated with Heat- and Drought-resistant Cattle (16/Oct/2019)
NCYT Amazings (Espanha): Hallados genes potencialmente vinculados con la resistencia de ganado bovino a las variaciones ambientales (23/Sep/2019)
Agro Rural News: Hallados genes potencialmente vinculados con la resistencia del ganado a las variaciones ambientales (23/Sep/2019)
Mundo Agropecuario (Venezuela): Hallados genes potencialmente vinculados con la resistencia del ganado a las variaciones ambientales (23/Sep/2019)
Perulactea (Peru): Hallados genes potencialmente vinculados con la resistencia del ganado a las variaciones ambientales (23/Sep/2019)
Economis (Argentina): Hallaron genes potencialmente vinculados con la resistencia del ganado a las variaciones ambientales (23/Sep/2019)
Acrissul - Associação dos Criadores do Mato Grosso do Sul: Estudo ajuda a identificar gado resistente às variações climáticas (12/Sep/2019)
Rural Pecuária: Pesquisadores do Brasil e da Austrália anunciaram a descoberta de 16 genes potencialmente associados com a resistência do gado Nelore (11/Sep/2019)
KLFF online: Estudo ajuda a identificar gado resistente às variações climáticas (11/Sep/2019)
Foco Rural: Estudo ajuda a identificar gado resistente às variações climáticas (11/Sep/2019)
Ioeste: Estudo ajuda a identificar gado resistente às variações climáticas (11/Sep/2019)
Ciência e Clima: Identificados genes potencialmente ligados à resistência do gado a variações ambientais (10/Sep/2019)
Casa Rural: Estudo ajuda a identificar gado resistente às variações climáticas. (10/Sep/2019)
TNH1: Estudo ajuda a identificar gados menos sensíveis ao ambiente (09/Sep/2019)
Compre Rural: Identificados genes potencialmente ligados à resistência do gado (06/Sep/2019)
Diario de Ciencias Aplicadas (Argentina): Genes potencialmente vinculados a la resistencia del ganado a variaciones ambientales identificadas (06/Sep/2019)
A Lavoura online: Estudo ajuda a identificar gado resistente às variações climáticas. (06/Sep/2019)
Brasil CT&I: Estudo ajuda a identificar gados menos sensíveis ao ambiente (06/Sep/2019)
Confap - Conselho Nacional das Fundações Estaduais de Amparo à Pesquisa: Identificados genes potencialmente ligados à resistência do gado a variações ambientais (05/Sep/2019)
Conexão Tocantins : Identificados genes potencialmente ligados à resistência do gado a variações ambientais (05/Sep/2019)
LabNetwork: Identificados genes potencialmente ligados à resistência do gado a variações ambientais (05/Sep/2019)
Portal CanaMix : Estudo ajuda a identificar gado resistente às variações climáticas. (05/Sep/2019)
Revista Analytica online: Estudo ajuda a identificar gado resistente às variações climáticas. (05/Sep/2019)
Portal Neo Mondo: Identificados genes potencialmente ligados à resistência do gado a variações ambientais (05/Sep/2019)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARVALHEIRO, ROBERTO; COSTILLA, ROY; NEVES, HAROLDO H. R.; ALBUQUERQUE, LUCIA G.; MOORE, STEPHEN; HAYES, BEN J. Unraveling genetic sensitivity of beef cattle to environmental variation under tropical conditions. GENETICS SELECTION EVOLUTION, v. 51, JUN 20 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.