Study of metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by immuno-histochemistry

• Grant number: 17/13167-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2017
• End date: November 30, 2018
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Fernanda Viviane Mariano Brum Corrêa
• Grantee: Larissa Fernandes Rosa
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry, AP.JP

Abstract

The pleomorphic adenoma (PA) is the most common tumor of the salivary gland and although benign, it has chances of recurrence and malignant transformation to carcinoma ex pleomorphic adenoma (CXPA). The latter is an aggressive neoplasm occurring with metastasis and death in a large percentage of cases. Although both tumors have important discoveries in genetic and molecular areas, the changes found are focal and in specific genetic sites. There are still many questions about the diagnostic market, pathogenesis and target therapy of PA and CXPA. Since the pathogenesis of cancer is characterized by a complex mix of genetic and metabolic changes, we will study various metabolic pathways (glucogenesis, lipogenesis) through immune-histochemical markers. This way, in this project, we will study a group of PAs and CXPAs (subdivided according to histological type and degree of progression) through the immune-histochemical reaction. With this approach, analyzing metabolic changes involved in tumorigenesis PA, CXPA carcinogenesis and tumor progression, we intend to add knowledge to what is known today expecting to discovery markers for diagnosis, pathogenesis and target therapy. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SCARINI, JOAO FIGUEIRA; ROSA, LARISSA FERNANDES; DE LIMA SOUZA, REYDSON ALCIDES; ABU EGAL, ERIKA SAID; TINCANI, ALFIO JOSE; MARTINS, ANTONIO SANTOS; KOWALSKI, LUIZ PAULO; GRANER, EDGARD; DELLA COLETTA, RICARDO; CARLOS, ROMAN; et al. Gene and immunohistochemical expression of HIF-1 alpha, GLUT-1, FASN, and adipophilin in carcinoma ex pleomorphic adenoma development. ORAL DISEASES, v. 26, n. 6, APR 2020. (15/07304-0, 17/00831-0, 17/13167-1)

SCARINI, JOAO FIGUEIRA; ABU EGAL, ERIKA SAID; DE LIMA-SOUZA, REYDSON ALCIDES; CRESCENCIO, LIVIA RAMALHO; EMERICK, CAROLINA; KOWALSKI, LUIZ PAULO; ALTEMANI, ALBINA; MARIANO, FERNANDA VIVIANE. Two sides of the same coin: Insights into the myoepithelial cells in carcinoma ex pleomorphic adenoma development. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, v. 157, JAN 2021. (15/07304-0, 17/00831-0, 17/13167-1)

ABU EGAL, ERIKA SAID; SCARINI, JOAO FIGUEIRA; DE LIMA-SOUZA, REYDSON ALCIDES; LAVAREZE, LUCCAS; FERNANDES, PATRICIA MARIA; EMERICK, CAROLINA; GONCALVES, MAYARA TREVIZOL; HELMS, MY N.; ALTEMANI, ALBINA; MARIANO, FERNANDA VIVIANE. Tumor microenvironment in salivary gland carcinomas: An orchestrated state of chaos. Oral Oncology, v. 127, p. 11-pg., 2022-02-18. (17/00831-0, 19/09419-0, 17/13167-1, 19/06809-2, 15/07304-0)