Understanding the exposome approach: from the concept to the applications in public health

• Grant number: 17/15797-2
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: October 02, 2017
• End date: December 01, 2017
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Kelly Polido Kaneshiro Olympio
• Grantee: Ana Paula Sacone da Silva Ferreira
• Supervisor: Dimosthenis A. Sarigiannis
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: Aristotle University of Thessaloniki (AUTh), Greece
• Associated to the scholarship: 16/07457-4 - Families inserted in local productive arrangement of the productive chain of jewelry and fashion jewelry from Limeira, SP: the occupational exposure to chemical contaminants in home setting, BP.MS

Abstract

The municipality of Limeira has a huge relevance in the productive chain of the jewelry and fashion jewelry industry, however, the informal outsourcing practices are very marked in that Local Productive Arrangement, which means improvised working conditions in households. Focusing on better understanding the complexity of the exposure to potentially toxic elements (PTEs) of families inserted in the informal and home productive arrangement in Limeira, in addition to starting the exposome study in Brazil by consolidating international collaboration with HEALS (Health and Environment-wide Associations based on Large Population Surveys), the aims of this internship are i) to perform untargeted omics analyses for the samples collected during the master degree study of the proponent and associated studies (FAPESP processes 2016/07457-4 and 2016/11087-8), aiming to understand the metabolic routes altered by chemical exposure ii) to accomplish the cohort study carried out by HEALS to know the exposome approach and then planning future studies related to the ongoing project entitled "From exposome up to Regulatory Toxicology: a thematic study of potentially toxic elements (PTEs) exposure of families inserted in informal and home productive arrangement in the jewelry and fashion jewelry chain from Limeira, SP" (FAPESP: 2016/11087-8) which includes the project "Families inserted in Local Productive Arrangement of the productive chain of jewelry and fashion jewelry from Limeira, SP: the occupational exposure to chemical contaminants in home setting" (FAPESP: 2016/07457-4). To achieve the aim "i" metabolomics and transcriptomic (LC-MS/MS and NMR) will be carried out for plasma samples and an intensive training with the HEALS investigator will be performed in order to enable the Brazilian research group to apply the exposome approach in the Limeira project. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KELLY POLIDO KANESHIRO OLYMPIO; FERNANDA JUNQUEIRA SALLES; ANA PAULA SACONE DA SILVA FERREIRA; ELIZEU CHIODI PEREIRA; ALLAN SANTOS DE OLIVEIRA; ISABELLE NOGUEIRA LEROUX; FLÁVIA BOSQUÊ ALVES VIEIRA. O expossoma humano desvendando o impacto do ambiente sobre a saúde: promessa ou realidade?. Revista de Saúde Pública, v. 53, 2019-01-31. (17/14392-9, 14/20945-2, 15/21253-0, 17/15797-2, 16/07457-4, 16/11087-8)

PEREIRA, ELIZEU CHIODI; FERREIRA, ANA PAULA SACONE DA SILVA; SATO, ANA PAULA SAYURI; FISCHER, FRIDA MARINA; OLYMPIO, KELLY POLIDO KANESHIRO. Home-based outsourced informal work by children and adolescents impacts sleep and leisure-a preliminary study. Environmental Science and Pollution Research, v. 27, n. 26, p. 8-pg., 2020-06-09. (16/11087-8, 17/14392-9, 17/15797-2)

PEREIRA, ELIZEU CHIODI; FERREIRA, ANA PAULA SACONE DA SILVA; SATO, ANA PAULA SAYURI; FISCHER, FRIDA MARINA; OLYMPIO, KELLY POLIDO KANESHIRO. Home-based outsourced informal work by children and adolescents impacts sleep and leisure-a preliminary study. Environmental Science and Pollution Research, v. 27, n. 26, SI, JUN 2020. (16/11087-8, 17/15797-2, 17/14392-9)

SACONE DA SILVA FERRREIRA, ANA PAULA; PEREIRA, ELIZEU CHIODI; SALLES, FERNANDA JUNQUEIRA; DA SILVA, FABIO FERREIRA; BATISTA, BRUNO LEMOS; HANDAKAS, EVANGELOS; KANESHIRO OLYMPIO, KELLY POLIDO. Home-based and informal work exposes the families to high levels of potentially toxic elements. Chemosphere, v. 218, p. 319-327, MAR 2019. (16/11087-8, 16/07457-4, 17/14392-9, 16/10060-9, 17/15797-2)