Targeting of functionalized nanoparticles in microfluidics systems containing multiple organoids

• Grant number: 17/21318-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: February 01, 2018
• End date: May 31, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Mateus Borba Cardoso
• Grantee: Iris Renata Sousa Ribeiro
• Host Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovação (Brasil). Campinas , SP, Brazil
• Associated scholarship(s): 19/18471-6 - Targeting functionalized nanoparticles towards 2D and 3D colorectal cancer models from cell lines and patient tumor biospecimens in microfluidics systems, BE.EP.DR

Abstract

Cancer is a disease with high mortality rate worldwide with approximately 8.2 million of deaths per year according to data from Instituto Nacional de Câncer (INCA). Chemotherapy is one of the main methods to treat this disease, however results in a high degree of toxicity. In this context, the use of nanoparticles (NPs) with functionalized ligands and incorporated drugs offers a powerful way for therapeutic purposes since they improve the therapeutic efficiency and the selectivity of the drug for tumor cells, minimizing the resistance imposed by the tumor cells against the drug and adverse collateral effects. However, an important limitation for biomedical application of NPs is their low kinetic stability. In order to overcome this limitation, the present project looks for remarkable advances in the development of chemically functionalized NPs with kinetic stabilizers and cell-specific ligands for selective interaction with tumor cells. The aim is to provide stability and selectivity to NPs in order to ensure the development of a promising alternative for cancer treatment. The studies will be conducted on an organ-on-a-chip platform, which consists of a microfluidic system incorporating synthetic in vitro tissues to simulate human physiology at the tissue and organ level. NPs will be placed in contact with healthy and tumoral organoids into microfluidic chips. In this way, more reliable evaluations of the action of the medicines in the organism can be provided through operation in organs-on-a-chip. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AFFONSO DE OLIVEIRA, JESSICA FERNANDA; DA SILVA, RAQUEL FRENEDOSO; SOUSA RIBEIRO, IRIS RENATA; SAITO, ANGELA; MELO-HANCHUK, TALITA DINIZ; DIAS, MARILIA MEIRA; KOBARG, JORG; CARDOSO, MATEUS BORBA. Selective Targeting of Lymphoma Cells by Monoclonal Antibody Grafted onto Zwitterionic-Functionalized Nanoparticles. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, v. 37, n. 3, FEB 2020. (14/22322-2, 15/25406-5, 13/22429-9, 17/21318-0)

RIBEIRO, IRIS RENATA SOUSA; DA SILVA, RAQUEL FRENEDOSO; RABELO, RENATA SANTOS; MARIN, TALITA MIGUEL; BETTINI, JEFFERSON; CARDOSO, MATEUS BORBA. Flowing through Gastrointestinal Barriers with Model Nanoparticles: From Complex Fluids to Model Human Intestinal Epithelium Permeation. ACS APPLIED MATERIALS & INTERFACES, v. 15, n. 30, p. 11-pg., 2023-07-19. (21/12071-6, 15/25406-5, 17/21318-0)

SOUSA RIBEIRO, IRIS RENATA; GALDINO, FLAVIA ELISA; SILVEIRA, CAMILA PEDROSO; CARDOSO, MATEUS BORBA. Precision medicine based on nanoparticles: the paradigm between targeting and colloidal stability. Nanomedicine, v. 16, n. 17, p. 6-pg., 2021-06-03. (15/25406-5, 17/21318-0, 19/14007-3, 18/09555-9)

SILVEIRA, CAMILA PEDROSO; SCHNEID, ANDRESSA DA CRUZ; RIBEIRO, IRIS RENATA SOUSA; GALDINO, FLAVIA ELISA; CARDOSO, MATEUS BORBA. A nano perspective behind the COVID-19 pandemic. NANOSCALE HORIZONS, v. 6, n. 11, AUG 2021. (19/14007-3, 15/25406-5, 18/00763-8, 17/21318-0, 18/09555-9)

REUS, THAMILE LUCIANE; MARCON, BRUNA HILZENDEGER; CAMPOS PASCHOAL, ARIANE CAROLINE; SOUSA RIBEIRO, IRIS RENATA; CARDOSO, MATEUS BORBA; DALLAGIOVANNA, BRUNO; DE AGUIAR, ALESSANDRA MELO. Dose-dependent cell necrosis induced by silica nanoparticles. TOXICOLOGY IN VITRO, v. 63, MAR 2020. (15/25406-5, 17/21318-0)

SCHNEID, ANDRESSA C.; RIBEIRO, IRIS R. S.; GALDINO, FLAVIA E.; BETTINI, JEFFERSON; CARDOSO, MATEUS B.. Degradable and colloidally stable zwitterionic-functionalized silica nanoparticles. Nanomedicine, JAN 2021. (17/21318-0, 18/09555-9, 18/00763-8, 15/25406-5)