Desferriosamine: albumin conjugates for the therapy of iron overload

• Grant number: 17/16379-0
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): March 01, 2018
• Effective date (End): December 31, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal researcher: Breno Pannia Esposito
• Grantee: Lucas Antonio Arias Correia
• Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Chelators currently employed in iron overload therapy have important side effects. Desferrioxamine (DFO), the main agent of this therapy, presents rapid renal clearance, without oral activity, which requires from patients prolonged and almost daily infusions. In this project, we aim to couple DFO to bovine serum albumin (BSA) and / or ovalbumin (OVA) through amino acids with amine or carboxyl-containing side groups. The final objective is to obtain conjugates that present lower renal clearance and, therefore, lower need for prolonged infusions to the patient. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CORREIA, LUCAS ANTONIO ARIAS; GARCIA, RODRIGO SANTOS; REAL, CAROLINE CRISTIANO; UZUELI, DANIEL HENRIQUE; SA, ULISSES LACERDA DE FIGUEIREDO; MARQUES, FABIO LUIZ NAVARRO; COLNAGO, LUIZ ALBERTO; ESPOSITO, BRENO PANNIA. Development of a platform for the production of multiple modal chelating and imaging agents using desferrioxamine and bovine albumin as a model. CHEMICAL PAPERS, v. 75, n. 3, p. 1157-1163, MAR 2021. Web of Science Citations: 0.