| Grant number: | 17/16379-0 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | March 01, 2018 |
| End date: | December 31, 2018 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry |
| Principal Investigator: | Breno Pannia Esposito |
| Grantee: | Lucas Antonio Arias Correia |
| Host Institution: | Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract Chelators currently employed in iron overload therapy have important side effects. Desferrioxamine (DFO), the main agent of this therapy, presents rapid renal clearance, without oral activity, which requires from patients prolonged and almost daily infusions. In this project, we aim to couple DFO to bovine serum albumin (BSA) and / or ovalbumin (OVA) through amino acids with amine or carboxyl-containing side groups. The final objective is to obtain conjugates that present lower renal clearance and, therefore, lower need for prolonged infusions to the patient. (AU) | |
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