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Dose, quality of induction and cardiopulmory effects using propofol in sheep premedicated with acepromazine or xylazine

Grant number: 17/17285-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2018
Effective date (End): December 31, 2018
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal researcher:Ewaldo de Mattos Junior
Grantee:Thaique Igor Bastianini
Home Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil


The aim of this study will be verify the dose, quality of anesthetic induction and cardiorespiratory effects using propofol in sheep premedicated with acepromazine or xylazine. Six female sheep, weighing 30 to 45 kg and 12 to 36 months of age, will be used, in a prospective, randomized and "cross-over" study, respecting a minimum interval of 1 week between treatments. The animals will be randomly assigned to three treatments, designated GP, GA and GX. In GP the animals will be induced to anesthesia with propofol in a sufficient dose that allows orotracheal intubation, in GA and GX they will be premedicated with acepromazine (0.1 mg/kg, IV) or xylazine (0.1 mg/kg, IV ) Respectively, and after 15 minutes induced anesthesia with propofol at a dose that allows orotracheal enbutation. The dose (in mg/kg) of propofol required for induction in all treatments, induction quality, cardiorespiratory effects (heart and respiratory rate, mean arterial pressure and rectal temperature) and blood gas analisys (pH, partial pressure of oxygen in arterial blood, partial pressure of carbon dioxide in arterial blood, arterial oxygen saturation, bicarbonate ion, base excess, sodium, potassium and chloride ions as well as period of latency, skillful anesthetic and quality of anesthetic recovery. All cardiorespiratory and hemogasometric variables will be verified and recorded at time 0 or baseline (without application of any drug), 10 minutes after administration of acepromazine or xylazine, and every 5 minutes after intubation until full recovery of the animals. The data will be submitted to D'Agostino Pearson's normality test and those with a parametric distribution will be analyzed with a two-way ANOVA test and, when necessary, Dunnet's post-test and the non-parametric Kruskal-Wallis test and post-test "Dunn's evidence." For comparison between treatments will be used ANOVA and Tukey post-test. The established level of significance will be 5%. (AU)

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