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Correlation between peripheral artery disease (PAD) in lower limbs and coronary artery disease (CAD): angiographic and impact evaluation on cardiovascular morbidity and mortality

Grant number: 17/15891-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2018
Effective date (End): January 31, 2019
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Marcone Lima Sobreira
Grantee:Matheus Zanarotti Adabo
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Context: Atherosclerosis is the major cause of cardiovascular diseases, responding for the first cause of death in the world. This includes peripheral artery disease (PAD) and coronary artery disease (CAD). There are several studies correlating the incidence, complexity and severity of artery disease between both arterial territories, lower limbs and coronary, in angiographic diagnosis. However, there are only few studies that approach this correlation trough the topography of all 3 lower limb arterial segments (aortoiliac, femoropopliteal and below-the-knee), as risk factors for coronary artery disease. As well, in these studies, there is no data concerning clinical findings impact on the angiographic classification often used, especially in PAD, which major relies on anatomic aspects of the arterial lesion. Objectives: To correlate the severity and extension of arterial disease in lower limb and coronary territories, verifying the topographic peripheral artery characteristics impact on prognosis of patients with both PAD and CAD Methods: Consists on transversal retrospective study of patients that have been submitted to angiography diagnosis for lower limbs and coronary arterial territories, in a public hospital - Hospital das Clínicas da Faculdade de Medicina de Botucatu (HC-FMB) - between July 2012 and July 2017. For analysis of coronary angiography, it will be applied the SYNTAX and SYNTAX II scores, and for lower limb angiography, TASC II score, including the last actualization, that includes below-the-knee segment. In addition, demographic and risk factor data, as well as clinical characterization, will be pooled for all patients, including exams performed in occasion of diagnosis. (AU)

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