Primary Macronodular Adrenocortical Hyperplasia: morphological, immunohistochemical study and its correlation with genetic-molecular alterations

• Grant number: 17/11495-1
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: March 01, 2018
• End date: February 29, 2020
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Maria Cláudia Nogueira Zerbini
• Grantee: Maria Luiza Anhaia de Arruda Botelho
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 15/50192-9 - Advances in the understanding of the pathophysiology of primary adrenocortical hyperplasia macronodular - PMAH (GP-PMAH), AP.TEM

Abstract

Primary Adrenal Macronodular Hyperplasia is a rare cause of ACTH-independent Cushing's Disease and has recently been found not to be entirely independent of ACTH secretion. Several groups have studied the molecular mechanisms involved in this disease, with the discovery of the ARMC5 gene mutation being the most recent finding. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BOTELHO, Maria Luiza Anhaia de Arruda. Primary macronodular adrenal hyperplasia: morphology, immunohistochemistry, and correlation with molecular genetic alterations. 2022. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.