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Primary Macronodular Adrenocortical Hyperplasia: morphological, immunohistochemical study and its correlation with genetic-molecular alterations

Grant number: 17/11495-1
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2018
Effective date (End): February 29, 2020
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal Investigator:Maria Cláudia Nogueira Zerbini
Grantee:Maria Luiza Anhaia de Arruda Botelho
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:15/50192-9 - Advances in the understanding of the pathophysiology of primary adrenocortical hyperplasia macronodular - PMAH (GP-PMAH), AP.TEM


Primary Adrenal Macronodular Hyperplasia is a rare cause of ACTH-independent Cushing's Disease and has recently been found not to be entirely independent of ACTH secretion. Several groups have studied the molecular mechanisms involved in this disease, with the discovery of the ARMC5 gene mutation being the most recent finding. (AU)