Influence of thiamine suplementation in oxidative stress, energetic metabolism and mortality among patients with septic shock

• Grant number: 17/21554-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2018
• End date: February 28, 2022
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Bertha Furlan Polegato
• Grantee: Amanda Gomes Pereira
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Introduction: thiamine (B1 vitamin) is a vitamin that acts as coenzyme for several enzymatic complexes involved in carbohydrates metabolism. Recently, thiamine deficiency has been related to critical situations, such as septic shock. Aims: to evaluate the influence of thiamine supplementation on oxidative stress, energy metabolism and mortality in patients with septic shock admitted to the intensive care unit. Patients and Methods: this is a prospective, controlled, double-blind, randomized study that included 116 patients diagnosed with septic shock admitted to the intensive care units (UCI) of Hospital das Clínicas, Botucatu Medical School. Patients will be allocated into two groups: thiamine supplementation and placebo. Thiamine will be administered intravenously, 200mg every 12 hours, for 5 days or until discharge from the ICU. The placebo will be administered in equivalent volume by the same route and period. Blood samples will be collected before and 48 hours after supplementation and the samples will be used to determine thiamine concentration, carbonyl protein, lipid hydroperoxide, activity of antioxidants enzymes and energetic metabolism enzymes. The primary endpoint to be evaluated will be mortality and as secondary outcomes, mechanical ventilation, vasoactive drug use, ICU stay and hospital stay will be assessed.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEREIRA, AMANDA GOMES; COSTA, NARA ALINE; GUT, ANA LUCIA; AZEVEDO, PAULA SCHMIDT; TANNI, SUZANA ERICO; ZORNOFF, LEONARDO ANTONIO MAMEDE; DE PAIVA, SERGIO ALBERTO RUPP; POLEGATO, BERTHA FURLAN; MINICUCCI, MARCOS FERREIRA. Urea to albumin ratio is a predictor of mortality in patients with septic shock. CLINICAL NUTRITION ESPEN, v. 42, p. 361-365, APR 2021. (17/21554-5, 14/17262-0)

PEREIRA, AMANDA G.; COSTA, NARA A.; AMANCIO, STEFANIE C. P.; OKOSHI, MARINA P.; ZORNOFF, LEONARDO A. M.; AZEVEDO, PAULA S.; MINICUCCI, MARCOS F.; DE PAIVA, SERGIO A. R.; POLEGATO, BERTHA F.. Effect of Thiamine on Clinical Outcomes in Septic Shock Patients: A Randomized, Double-Blinded Pilot Study. American Journal of Respiratory and Critical Care Medicine, v. 208, n. 5, p. 3-pg., 2023-09-01. (17/21554-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PEREIRA, Amanda Gomes. Influence of thiamine supplementation on mortality in septic shock patients. 2022. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.