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Dissecting the causal role of anthropometric traits in the risk of posttraumatic stress disorder in women

Grant number: 18/05995-4
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): August 06, 2018
Effective date (End): May 09, 2019
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal researcher:Síntia Iole Nogueira Belangero
Grantee:Carolina Muniz Felix de Carvalho
Supervisor abroad: Renato Polimanti
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Research place: U.S. Department of Veterans Affairs, United States  
Associated to the scholarship:15/26473-8 - Search for genetic, epigenetic and molecular markers of post-traumatic stress disorder, BP.DR


Women's higher risk for Posttraumatic stress disorder (PTSD) likely arises from biologic and social/environmental factors. The current results of PTSD GWAS have indicated that there are genetic differences between women and men in the predisposition to PTSD. Polimanti and colleagues (2017) observed a strong causal association between female body shape (anthropometric traits) and the risk to develop PTSD. We hypothesized that female-specific genetic factors contribute to this sex-difference in the genetics of PTSD. Our aim is to investigate the causal relationship of anthropometric traits in the risk of PTSD in women. To evaluate this hypothesis, we will conduct a genome-wide polygenic risk score (PRS) and Mendelian randomization (MR) analyses in PTSD female sample from the Psychiatric Genomics Consortium and PTSD Brazilian cohort, using GWAS summary statistics of female-specific traits together with a mixture-of- experts machine learning framework for MR. We will also use appropriate computation methods to investigate cohorts including individuals with different ancestral backgrounds. All techniques, analyses and the bioinformatics training will be developed in collaboration with Dr. Renato Polimanti's group in the Division of Human Genetics (Psychiatry) at Yale University School of Medicine. The results of this study may help to identify potential genetic markers of vulnerability to PTSD and to find the gender differences associated with PTSD. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARVALHO, CAROLINA MUNIZ; WENDT, FRANK R.; MAIHOFER, ADAM X.; STEIN, DAN J.; STEIN, MURRAY B.; SUMNER, JENNIFER A.; HEMMINGS, SIAN M. J.; NIEVERGELT, CAROLINE M.; KOENEN, KARESTAN C.; GELERNTER, JOEL; et al. Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social support. NEUROPSYCHOPHARMACOLOGY, v. 46, n. 6, . (18/05995-4)
CARVALHO, CAROLINA MUNIZ; WENDT, FRANK R.; STEIN, DAN J.; STEIN, MURRAY B.; GELERNTER, JOEL; BELANGERO, SINTIA I.; POLIMANTI, RENATO. Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study. Molecular Neurobiology, v. 57, n. 3, . (18/05995-4)
WENDT, FRANK R.; CARVALHO, CAROLINA MUNIZ; PATHAK, GITA A.; GELERNTER, JOEL; POLIMANTI, RENATO. Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders. JOURNAL OF CLINICAL MEDICINE, v. 8, n. 12, . (18/05995-4)
CARVALHO, CAROLINA MUNIZ; WENDT, FRANK R.; PATHAK, GITA A.; MAIHOFER, ADAM X.; STEIN, DAN J.; SUMNER, JENNIFER A.; HEMMINGS, SIAN M. J.; NIEVERGELT, CAROLINE M.; KOENEN, KARESTAN C.; GELERNTER, JOEL; et al. Disentangling sex differences in the shared genetic architecture of posttraumatic stress disorder, traumatic experiences, and social support with body size and composition. NEUROBIOLOGY OF STRESS, v. 15, . (18/05995-4)

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