Effect of dimethyl fumarate in the evolution of autoimmune experimental encephalomyelitis. activation of Regulatory T cells in intestinal mucosa

• Grant number: 18/03432-2
• Support Opportunities: Scholarships in Brazil - Master
• Start date: June 01, 2018
• End date: February 29, 2020
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Leonilda Maria Barbosa dos Santos
• Grantee: Amanda Dias da Rocha Lima
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

In vivo administration of dimethyl fumarate (DMF) significantly reduces the severity of autoimmune experimental encephalomyelitis (EAE). Recent studies have shown that reducing the severity of EAE by treatment with DMF is due to the fact that monomethil fumarate (MMF) reduces the production of proinflammatory cytokines by the stimulation of HCAR2 receptor present in dendritic cells. Since DMF is metabolized in MMF in the intestine, it is possible that this drug also activates the anti-inflammatory response in the intestinal mucosa, which interferes with the evolution of the autoimmune disease of the central nervous system (CNS). The intestinal epithelial cells also express HCAR2. In this proposal it is our objective to study whether MMF through binding with HCAR2 reduces the production of proinflammatory cytokines, induces the activation of regulatory T lymphocytes and the production of PGE2 in the intestinal mucosa of mice with EAE and the consequent inhibition of the evolution of the disease of the CNS. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

LIMA, Amanda Dias da Rocha. Effect of dimethyl fumarate in the evolution of experimental autoimmune encephalomyelitis: ativation of regulatory T cells in intestinal mucosa?. 2020. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.