Analysis of polymorphisms of Leishmania (L.) infantum chagasi, through the microsatellite technique, in samples from bone marrow from patients from the State of São Paulo, with visceral leishmaniasis

• Grant number: 18/05758-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2018
• End date: December 31, 2019
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal Investigator: José Angelo Lauletta Lindoso
• Grantee: Vinícius Alves de Lima
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

In Brazil, visceral leishmaniasis (LV) is caused by Leishmania (Leishmania) infantum chagasi, and a change in its epidemiological profile has been observed in the last decades. It has ceased to be a predominantly rural disease and has spread to urban areas. After observing the phenomenon of LV urbanization (1, 2, 7), there is a record of increased lethality, especially in areas previously without notification of autochthonous transmission (7). In Brazil, different genotypes are observed in samples from dogs and sand flies, relating them to the respective geographical regions of origin (3, 4). The existence of genetic heterogeneity in the populations of several species of Leishmania sp. is a confirmed fact. There is no correct pre-implantation of the molecular epidemiology of VL, however, as the Leishmania (Leishmania) infantum chagasi presents high genotype plasticity in its genotypic profile, there is the possibility of convergence in relation to the geographical area. This justifies the present proposal that is part of the research project of Prof. Dr. José Angelo Lauleta Lindoso and the master's dissertation of his student Renata Ellen Costa da Silva titled "Evaluation of the genotypic profile of Leishmania (Leishmania) infantum of patients from different areas of transmission".

Scientific publications

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VINICIUS ALVES LIMA; RENATA ELEN COSTA SILVA; LUIZ HENRIQUE MORAES CAETANO CAMARGO; ROBERTO MITSUYOSHI HIRAMOTO; ELCIO DE SOUZA LEAL; LUCIA MARIA ALMEIDA BRAZ; JOSÉ ANGELO LAULETTA LINDOSO. Genetic variability of Leishmania (Leishmania) infantum causing human visceral leishmaniasis in the Southeastern Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 65, 2023-10-20. (16/03165-9, 18/05758-2)