Modulating effect of indomethacin incorporated into silica nanoparticle in the regulation of inflammation mediators

• Grant number: 18/00840-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2018
• End date: April 30, 2019
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Ricardo Andrade Furtado
• Grantee: Edna de Sousa Neves
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

Indomethacin is described as a non-steroidal anti-inflammatory class drug. It has a good bioavailability, can reduce fever, pain and swelling. The mesoporous silica structures are being studied by the capacity of bioconjugation with different molecules, being distinguished by the fact that it has the capacity to penetrate the cell membrane and by the high efficiency in the incorporation of several therapeutic agents, which can be released controlled at the sites target. In this sense, the present work aims to evaluate the modulatory potential of indomethacin incorporated into mesoporous silica nanoparticles on the production of chemical mediators in peritoneal macrophages. For this purpose, peritoneal macrophages will be cultured in plates and the supernatant will be collated for evaluation of the stimulation of the production of mediators of inflammation. Thus, this work will contribute to a better understanding of the action of indomethacin incorporated into mesoporous silica nanoparticles, providing its most effective and safe use in future clinical applications.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JUNIOR, SILVIO ALMEIDA; PEREIRA, POLIANA MARQUES; TOTOLI, VANESSA DE SOUZA; NEVES, EDNA SOUSA; MONOCHIO, MAYARA; ALVARENGA, ALEF WINTER OLIVEIRA; HORI, JULIANA ISSA; BRAZ, WILSON RODRIGUES; ROCHA, LUCAS ALONSO; NASSAR, EDUARDO JOSE; et al. Incorporation of indomethacin into a mesoporous silica nanoparticle enhances the anti-inflammatory effect Indomethacin into a mesoporous silica. European Journal of Pharmaceutical Sciences, v. 157, FEB 1 2021. (18/00840-2, 17/10241-6, 17/22919-7)