|Support type:||Scholarships in Brazil - Scientific Initiation|
|Effective date (Start):||May 01, 2018|
|Effective date (End):||April 30, 2019|
|Field of knowledge:||Biological Sciences - Pharmacology - General Pharmacology|
|Principal Investigator:||Ricardo Andrade Furtado|
|Grantee:||Edna de Sousa Neves|
|Home Institution:||Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil|
Indomethacin is described as a non-steroidal anti-inflammatory class drug. It has a good bioavailability, can reduce fever, pain and swelling. The mesoporous silica structures are being studied by the capacity of bioconjugation with different molecules, being distinguished by the fact that it has the capacity to penetrate the cell membrane and by the high efficiency in the incorporation of several therapeutic agents, which can be released controlled at the sites target. In this sense, the present work aims to evaluate the modulatory potential of indomethacin incorporated into mesoporous silica nanoparticles on the production of chemical mediators in peritoneal macrophages. For this purpose, peritoneal macrophages will be cultured in plates and the supernatant will be collated for evaluation of the stimulation of the production of mediators of inflammation. Thus, this work will contribute to a better understanding of the action of indomethacin incorporated into mesoporous silica nanoparticles, providing its most effective and safe use in future clinical applications.