Nanotechnology applied to elaboration of synthetic acaricides associated with plant isolates for the control of Rhipicephalus (b.) microplus

• Grant number: 17/13249-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: May 01, 2018
• End date: December 31, 2020
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Principal Investigator: Ana Carolina de Souza Chagas
• Grantee: Amanda Figueiredo
• Host Institution: Embrapa Pecuária Sudeste. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil

Abstract

As a result of parasitism, Rhipicephalus (Boophilus) microplus causes high losses in national cattle production, estimated to be approximately $ 3.24 billion per year. In recent years, due to excessive use of synthetic products, scientific reports of resistance to commercial antiparasitics have increased and is one of the most worrisome factors in ruminant production systems. The excessive use of synthetic products is still related to food safety, where the presence of residues in food of animal origin can compromise human health and for this reason the demand for organic food has been increasing. Thus, researches focusing on new active molecules present in plant extracts for control of the bovine tick have intensified. However, results of high efficacy in vitro are not repeated in vivo and therefore, suitable formulations need to be studied, developed and evaluated. Nanocarriers allow the improvement of the bioavailability of actives compounds, such as increasing aqueous solubility, improving tissue absorption and distribution processes, reducing thus possible toxic effects. In this way, the present project aims to evaluate the acaricidal potential of formulations developed from nanocarriers systems based on cypermethrin + chlorpyrifos and its association with bioactives isolated from plants, in addition to attempt to reduce the residual period and the dose to reach the same efficacy. It is expected in the present proposal to advance in this research area, developing systems (lipid carriers and zein nanoparticles) in which new molecules can be incorporated and evaluated for parasitic control. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

YOUSMEL ALEMÁN GAINZA; ISABELLA BARBOSA DOS SANTOS; AMANDA FIGUEIREDO; LEONARDO APARECIDO LIMA DOS SANTOS; SÉRGIO NOVITA ESTEVES; WALDOMIRO BARIONI-JUNIOR; ALESSANDRO PELEGRINE MINHO; ANA CAROLINA DE SOUZA CHAGAS. Resistência anti-helmíntica de Haemonchus contortus em rebanhos ovinos no Brasil: concordância de métodos in vivo e in vitro (RESISTA-Test©). Revista Brasileira de Parasitologia Veterinária, v. 30, n. 2, 2021-05-03. (18/16070-1, 17/13249-8, 14/25821-0, 16/07132-8)

NOGUEIRA, JEANE A. P.; FIGUEIREDO, AMANDA; DUARTE, JONATAS L.; DE ALMEIDA, FERNANDA B.; SANTOS, MARCELO G.; NASCIMENTO, LEONOR M.; FERNANDES, CAIO P.; MOURAO, SAMANTA C.; TOSCANO, JOAO HENRIQUE B.; ROCHA, LEANDRO M.; et al. Repellency effect of Pilocarpus spicatus A. St.-Hil essential oil and nanoemulsion against Rhipicephalus microplus larvae. Experimental Parasitology, v. 215, AUG 2020. (17/00373-2, 17/13249-8)

LOPES, LOUYSE G.; SILVA, MATHEUS H.; FIGUEIREDO, AMANDA; CANUTO, KIRLEY M.; BRITO, EDY S.; RIBEIRO, PAULO R. V.; SOUZA, ANA S. Q.; BARIONI-JUNIOR, WALDOMIRO; ESTEVES, SERGIO N.; CHAGAS, ANA CAROLINA S.. The intake of dry cashew apple fiber reduced fecal egg counts in Haemonchus contortus-infected sheep. Experimental Parasitology, v. 195, p. 38-43, DEC 2018. (17/13249-8)

FIGUEIREDO, AMANDA; ANHOLETO, LUIS ADRIANO; COLA, DIEGO FARIA; FANTATTO, RAFAELA REGINA; SANTOS, ISABELLA BARBOSA; GAINZA, YOUSMEL ALEMAN; SOUSA, GUSTAVO AVELAR; PICKETT, LAURA JANE; FRACETO, LEONARDO FERNANDES; CHAGAS, ANA CAROLINA DE SOUZA. Nanoformulations with synthetic and plant-derived compounds for cattle tick control. Veterinary Parasitology, v. 309, p. 9-pg., 2022-09-01. (17/21004-5, 19/20185-1, 17/13249-8)

FIGUEIREDO, AMANDA; ANHOLETO, LUIS ADRIANO; COLA, DIEGO FARIA; FANTATTO, RAFAELA REGINA; GAINZA, YOUSMEL ALEMAN; DOS SANTOS, ISABELLA BARBOSA; VICOZZI, GABRIEL PEDROSO; AVILA, DAIANA SILVA; FRACETO, LEONARDO FERNANDES; CHAGAS, ANA CAROLINA DE SOUZA. Acaricides containing zein nanoparticles: A tool for a lower impact control of the cattle tick Rhipicephalus microplus. Veterinary Parasitology, v. 318, p. 11-pg., 2023-04-11. (19/20185-1, 18/16070-1, 17/13249-8, 17/21004-5)

SANTOS, ISABELLA B.; FERREIRA, AVELARDO U. C.; RABELO, MARCIO D.; ANHOLETO, LUIS ADRIANO; SOUSA, GUSTAVO A.; GAINZA, YOUSMEL A.; FIGUEIREDO, AMANDA; ESTEVES, SERGIO N.; CHAGAS, ANA CAROLINA S.. Portable near-infrared spectroscopy: A rapid and accurate blood test for diagnosis of Haemonchus contortus infection and for targeted selective treatment of sheep. International Journal for Parasitology, v. 53, n. 2, p. 9-pg., 2023-02-17. (17/13249-8, 16/07132-8, 18/16070-1, 19/02929-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FIGUEIREDO, Amanda. Nanotechnology applied to development of synthetic acaricides associated with plants compounds for the Rhipicephalus (Boophilus) microplus control. 2020. Doctoral Thesis - Universidade Estadual Paulista (Unesp).