| Grant number: | 18/11963-8 |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| Start date: | October 20, 2018 |
| End date: | May 19, 2019 |
| Field of knowledge: | Health Sciences - Medicine - Psychiatry |
| Principal Investigator: | Beny Lafer |
| Grantee: | Camila Nascimento Mantelli |
| Supervisor: | Gustavo Turecki |
| Host Institution: | Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Institution abroad: | McGill University, Montreal, Canada |
| Associated to the scholarship: | 17/07089-8 - Investigating TDP-43 as neuromarker of Bipolar Disorder, BP.PD |
Abstract Children in our society are all too often subjected to physical violence, emotional deprivation and inappropriate sexual behaviors. These negative life experiences are among the strongest predictors of psychiatric illness, aggressive and violent behaviors including suicide in adulthood, with strong and lifelong effects. Recent research has suggested that early-life adversity may influence development of certain personality traits and negative mental health outcomes by changing the chemical structure of DNA. These effects, known as epigenetics were initially observed in animal studies and subsequent research suggested that they also occur in humans. The study will use a combination of high throughput techniques, including single-cell sequencing, followed by epigenome analysis, aiming to identify epigenetic changes associated with early environmental adversity. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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