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Study of alterations in lipolytic response and glyceroneogenesis in adipose territories of different anatomical locations induced by chronic iatrogenic hypercortisolism

Grant number: 18/16856-5
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): September 01, 2018
Effective date (End): March 31, 2021
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Fabio Bessa Lima
Grantee:Ayumi Cristina Medeiros Komino
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:16/25129-4 - Iatrogenic Chronic Hypercortisolism and its implications to the adipose tissue plasticity an analysis of the dynamics of adipose tissue distribution in an experimental model of Cushing's Syndrome, AP.TEM

Abstract

Glucocorticoids are steroid hormones secreted by the adrenal cortex. They are essential for various vital functions, and both their excess and their absence are life-threatening. Excessive systemic glucocorticoids are known as Cushing's Syndrome, a disorder with numerous complications, many of which are linked to lipid metabolism, and adipose tissue plays a central role. Thus, highly active pathways in adipocytes, such as lipolysis and glyceroneogenesis, may have a role in the pathophysiology of this disease. In order to evaluate the contribution of these pathways and different adipose territories, taking into account that different territories have different characteristics, this project aims by means of morphometric analysis, biological assays with isolated adipocytes, gene expression, protein and enzymatic activity, characterize the changes which are caused under chronic exposure to glucocorticoids, since there are few studies in the literature with animal models of such syndrome, especially in relation to the analysis of the lipolytic response and, mainly, the role of glyceroneogenesis in altering the plasticity of adipose tissue (that is, in induction of greater visceral central adiposity and reduction of peripheral adipose mass). In addition, the understanding of these pathways may elucidate the mechanism of other pathologies that exhibit similar characteristics with Cushing's Syndrome, such as the Metabolic Syndrome. (AU)