Quantification of paramagnetic ions in human cerebral tissue: correlation with magnetic resonance images

• Grant number: 18/10103-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2018
• End date: June 30, 2019
• Field of knowledge: Physical Sciences and Mathematics - Physics
• Principal Investigator: Carlos Ernesto Garrido Salmon
• Grantee: Fábio Seiji Otsuka
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The quantitative susceptibility mapping (QSM) has been proposed in studies and diagnosys of some neurodegeneratives diseases (like the Parkinsons Disease) because it is sensitive to the content of metals in the brain (related to those diseases, according to studies). The EPR (Electron paramagnetic Resonance), together with the QSM in postmortem studies, enables a more detailed study about metals in brain, their ionic states and the metalloproteins associated.