Evaluation of poloxamer-based ropivacaine gel formulations in a post operative pain model

• Grant number: 18/12870-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2018
• End date: July 31, 2019
• Field of knowledge: Biological Sciences - Pharmacology - Clinical Pharmacology
• Principal Investigator: Giovana Tofoli Moniz
• Grantee: Beatriz Furlan
• Host Institution: Centro de Pesquisas Odontológicas São Leopoldo Mandic. Faculdade São Leopoldo Mandic (SLMANDIC). Sociedade Regional de Ensino e Saúde S/S Ltda (SRES). Campinas , SP, Brazil
• Associated research grant: 14/14457-5 - Lipid-based nanocarriers (SLN/NLC and remote-loading liposomes) used to improve the upload and potency of local anesthetics, AP.TEM

Abstract

In the last decades the development of drug-delivery systems, such as thermoreversible gels made it possible to manipulate some biopharmaceutical and pharmacological properties of drugs, improving their therapeutic effects (long duration of action associated to low systemic toxicity) and their clinical use. Local anesthtetics, such as ropivacaine, are widely used in clinical medicine. However, these drugs can induce convulsions and arrhythmia due to sodium channels blockade. The use of poloxamers to form thermoreversible gels, would be interesting due to its capacity of improve the pharmacological properties of this local anesthetic and the possibility of alterations in the posology of this drug, being potentially advantageous for the pain relief. Thus, the aim of this study is to evaluate ropivacaine associated with poloxamers in a post-operative pain model in rats. (AU)