ARFI elastography of the hepatic and splenic tissues of canine patients affected by brachycephalic syndrome

• Grant number: 17/24809-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2018
• End date: July 31, 2020
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Paola Castro Moraes
• Grantee: Andréia Coutinho Facin
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
• Associated scholarship(s): 19/07087-0 - Correlation between nasal stenosis and nasal cavity tissue density based on CT and rhinoscopy of brachycephalic dogs, BE.EP.MS

Abstract

Considered an animal welfare problem, brachycephalic syndrome (BS) is common in the clinical routine of small animals and has received public attention in recent years. With positive surgical results, the BS can be attenuated, but little is known about the systemic effects caused when the surgical correction is not performed early. This syndrome is compared with the obstructive sleep apnea (OSA) in humans, both of which are considered as causes of systemic and metabolic dysfunction. Due to the growing concern of human medicine regarding the hepatic injury of patients affected by OSA and, given the lack of studies of the effects of BS in dogs, this preliminary study aims to evaluate the consequences of BS in the hepatic and splenic parenchyma of brachycephalics dogs that don't have be treated surgically. The methodology will be based in ARFI elastography using the ACUSON S2000/SIEMENS device, with convex and linear multifrequential transducers, and specific softwares, as well as clinical evaluation of the syndrome in order to determine if they can be used as a prognostic non-invasive tool. Patientes with age between one and eight years will be selected, 15 healthy French Bulldogs and 15 Pugs, that do not undergo of any type of surgical treatment of BS will be used and fifteen healthy dolichocephalic patients, with body height similar as the brachycephalic breeds and maximum weight of 15 kilograms.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FACIN, ANDREIA COUTINHO; RAMIREZ USCATEGUI, RICARDO ANDRES; MARONEZI, MARJURY CRISTINA; PAVAN, LETICIA; MENEZES, MARELIZA POSSA; MONTANHIM, GABRIEL LUIZ; CAMACHO, APARECIDO ANTONIO; ROSSI FELICIANO, MARCUS ANTONIO; MORAES, PAOLA CASTRO. Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers. SCIENTIFIC REPORTS, v. 10, n. 1, SEP 30 2020. (17/24809-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FACIN, Andréia Coutinho. Acoustic Radiation Force Impulse (ARFI) elastography of the hepatic and splenic tissues of canine patients affected by brachycephalic syndrome. 2020. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.