Organogels LECITIN-POLOXAMER-BASED for skin delivery: development, ex vivo permeation profile and stratum corneum structural evaluation

• Grant number: 18/04036-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: November 01, 2018
• End date: January 31, 2020
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Daniele Ribeiro de Araujo
• Grantee: Aryane Alves Vigato
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated research grant: 14/14457-5 - Lipid-based nanocarriers (SLN/NLC and remote-loading liposomes) used to improve the upload and potency of local anesthetics, AP.TEM

Abstract

Topical and transdermal routes are important strategies for drug administration, since they are non-invasive, avoid first-pass biotransformation and enable the use of self-administered pharmaceutical forms, which improves patient compliance. However, the clinical efficacy of this type of administration depends on the drug physico-chemical and pharmacological properties, as well as its bioavailability at the site of action, which is limited by the low permeability of the stratum corneum. Organogels are semi-solid systems, in which an organic phase is immobilized by a three-dimensional network composed of self-organized system, forming the aqueous phase. These gels have advantages over conventional systems (creams, ointments, hydrogels), such as modulation of the rate and time of permeation, as well as affinity for the site of administration, according to adjustments in their composition. In this context, lipid and poloxamer (PLs) organogels form a two-phase system which can be effectively used as skin delivery systems for hydrophilic and lipophilic drugs, favoring their permeation across the stratum corneum. In this way, this project proposes the development of a system for dual drug-release considering the application of curcuminoid derivatives, as antioxidant and anti-inflammatory drugs, and lidocaine, a local anesthetic, aiming a pharmacological synergistic effect for the treatment of topical lesions (surgical incisions, dermatological inflammatory processes such as atopic dermatitis, psoriasis). All formulations will be studied by physico-chemical techniques, drug permeation profile and the stratum corneum structural evaluation.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VIGATO, ARYANE ALVES; QUEROBINO, SAMYR MACHADO; DE FARIA, NAIALLY CARDOSO; PINHEIRO DE FREITAS, ANDREA CAROLINA; LEONARDI, GISLAINE RICCI; DE PAULA, ENEIDA; SAIA CEREDA, CINTIA MARIA; TOFOLI, GIOVANA RADOMILLE; DE ARAUJO, DANIELE RIBEIRO. Synthesis and characterization of nanostructured lipid-poloxamer organogels for enhanced skin local anesthesia. European Journal of Pharmaceutical Sciences, v. 128, p. 270-278, FEB 1 2019. (18/02482-6, 14/14457-5, 18/04036-3)

VIGATO, ARYANE ALVES; QUEROBINO, SAMYR MACHADO; DE FARIA, NAIALLY CARDOSO; BOLELA BOVO CANDIDO, ANA CAROLINA; MAGALHAES, LIZANDRA GUIDI; SAIA CEREDA, CINTIA MARIA; TOFOLI, GIOVANA RADOMILLE; RAMOS CAMPOS, ESTEFANIA VANGELIE; MACHADO, IAN POMPERMAYER; FRACETO, LEONARDO FERNANDES; et al. Physico-Chemical Characterization and Biopharmaceutical Evaluation of Lipid-Poloxamer-Based Organogels for Curcumin Skin Delivery. FRONTIERS IN PHARMACOLOGY, v. 10, SEP 12 2019. (18/04036-3, 16/24456-1, 16/18045-9, 18/02482-6, 14/14457-5)