Comparison among the effects of different coinduction protocols on induction to anesthesia with a bolus of propofol in cats

• Grant number: 18/07455-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2018
• End date: September 30, 2019
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Beatriz Perez Floriano
• Grantee: Anna Luíza Zavataro e Silva
• Host Institution: Centro Universitário Faculdades Integradas de Ourinhos. Fundação Educacional Miguel Mofarrej. Ourinhos , SP, Brazil

Abstract

Coinduction to general anesthesia is a technique commonly used by anesthesiologists and comprises the use of two or more agents in order to reduce general anesthetic requirements. The objective of this study is to compare the efficacy of different coinduction agents on the duration of a single propofol bolus for anesthetic induction of healthy cats. Animals will be included in the study according to clinical tests and will participate in five experimental groups with 7-day intervals. Following premedication with dexmedetomidine at 10 mg/kg, induction to anesthesia will follow the same pattern in all groups, starting with a propofol bolus at a constant rate of 1 mg/kg/minute followed by the coinduction agent (fentanyl 1 µg/kg, midazolam 0.3 mg/kg, ketamine 2 mg/kg, and saline solution or control group). A 30-second period will be awaited prior to further propofol administration, which will be carried out to effect until the eye bulb is rotated, the palpebral reflex is lost and orotracheal intubation is possible. In all groups, the following variables will be recorded: time to extubation (minutes), time to return of the palpebral reflex (minutes), time to eye bulb centralization (minutes), time to regain conscience (minutes), time to recover to a standing position (minutes) and total dose of propofol (mg/kg). At the end of the study, the four groups will be compared through analysis of variance followed by Tukey test under 5% significance. This project was idealized for 12 months and the results will be published at journals and scientific events.