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Analgesic and anti-inflammatory efficacy of lidocaine administered at acupuncture points compared to intravenous route in dogs with pyometra

Grant number: 18/13116-0
Support type:Regular Research Grants
Duration: February 01, 2019 - July 31, 2021
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal researcher:Renata Navarro Cassu
Grantee:Renata Navarro Cassu
Home Institution: Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade do Oeste Paulista (UNOESTE). Presidente Prudente , SP, Brazil
Assoc. researchers:Stelio Pacca Loureiro Luna

Abstract

The aim of this study is to evaluate the analgesic and anti-inflammatory efficacy of lidocaine administered at acupuncture points compared to intravenous (IV) route in dogs. Thirty dogs undergoing ovariohysterectomy diagnosed with pyometra will be included in the study. For the surgical procedure the dogs will be sedated with methadone (0.3 mg/kg) administered by intramuscular (IM) route. Anesthesia will be induced with propofol and maintained with isoflurane/O2. Five minutes after induction of anesthesia the dogs will be distributed into three groups: LIV (n=10): IV lidocaine 1% infusion (loading dose of 2 mg/kg, followed by a constant rate infusion of 50µg/kg/min); LAP (n=10): subcutaneous lidocaine 1% (1 mg/kg) will be injected bilaterally at ST36 and SP6 acupoints; SAL (n=10): IV saline infusion (loading dose of 2 mL/kg, followed by a constant rate infusion of 2mL/kg/min). The degree of analgesia and sedation will be measured before (baseline), 1, 2, 4, 8, 12, 18 and 24 hours after extubation. Rescue analgesia will be provided with IM methadone (0.3 mg/kg). Blood serum levels of interleukin (IL-6 and IL-10) tumor necrosis factor-a (TNF-a) and C-reative protein will be measured at baseline, 6, 12 and 24 hours after surgery. Numerical data will be submitted to analysis of variance followed by Tukey's test for parametric measures and Kruskall-Wallis with post-Dunn test for nonparametric measures (p <0.05). (AU)