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Synthesis and characterization of calcium phosphate nanoparticles loaded with chlorhexidine

Grant number: 18/19526-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2018
Effective date (End): October 31, 2019
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Letícia Cristina Cidreira Boaro
Grantee:Selma Regina Muniz Freitas
Home Institution: Universidade de Santo Amaro (UNISA). São Paulo , SP, Brazil


The present project aims to develop a particle that presents remineralizing and antimicrobial characteristics through the synthesis of a nanoparticle of amorphous calcium phosphate loaded with chlorhexidine. Two methods of synthesizing chlorhexidine-loaded nanoparticles will be tested, the methods will be Synthesis per se and incorporation. At the end of the synthesis processes we will have four different particles that will be tested in Elisa plate (96 wells) in different concentrations and in which the microorganism Streptococcus mutans will be added. The minimum inhibition concentration will be considered the lowest concentration of antimicrobial agent added to the composites in which there is no visible growth.