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Coronary bifurcations geometry: an exploratory study of the mathematical laws to estimate the vascular dimensions in coronary bifurcations

Grant number: 18/14221-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date: November 01, 2018
End date: October 31, 2019
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Pedro Alves Lemos Neto
Grantee:Gabriela Hidalgo Vargas dos Santos
Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

In medical practice, the knowledge of the vascular dimensions has a great relevance, because in cardiovascular interventions the treatment devices (stents, balloons) have to be dimensioned in concordance to the expected size of the vessel in which the intervention will occur, otherwise, the risk of adverse effects is enhanced. In this context, the possibility to predict the original radius of a sick vessel based on the radius of the vessels related to it can be important in medical interventions. Scientists like Murray proposed mathematical laws derived from fluid mechanics willing to mathematically correlate the diameter of the main vessel to the diameter of its branches. The "Murray's Law" states that: r03= r13 + r23, which means that the cubic root of the main vessel 's radius is equal to the sum of the cubic roots of its branches radius. Few studies, however, validated this law in humans. Therefore, the objective of this study is to evaluate, trough the analysis of left coronary artery (LCA) and its branches (LAD and LCX) radius the application of Murray's law to human vessels and to estimate other potential equations that can adequately correlate the dimensions of coronary arteries and its bifurcations.

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MUELLER, LUCAS O.; WATANABE, SANSUKE M.; TORO, ELEUTERIO F.; FEIJOO, RAUL A.; BLANCO, PABLO J.. An anatomically detailed arterial-venous network model. Cerebral and coronary circulation. FRONTIERS IN PHYSIOLOGY, v. 14, p. 19-pg., . (18/14221-2, 14/50889-7)
BLANCO, PABLO J.; VARGAS DOS SANTOS, GABRIELA H.; BULANT, CARLOS A.; ALVAREZ, ALONSO M.; OLIVEIRA, FREDRIC A. P.; CUNHA-LIMA, GABRIELLA; LEMOS, PEDRO A.. caling laws and the left main coronary artery bifurcation. A combination of geometric and simulation analyse. MEDICAL ENGINEERING & PHYSICS, v. 99, . (18/14221-2, 14/50889-7)
NOROOZBABAEE, LEYLA; BLANCO, PABLO J.; SAFAEI, SOROUSH; NICKERSON, DAVID P.. A modular and reusable model of epithelial transport in the proximal convoluted tubule. PLoS One, v. 17, n. 11, p. 30-pg., . (14/50889-7, 18/14221-2)
VELLASCO, LUCAS; SVENSJO, ERIK; BULANT, CARLOS ALBERTO; BLANCO, PABLO JAVIER; NOGUEIRA, FABIO; DOMONT, GILBERTO; DE ALMEIDA, NATALIA PINTO; NASCIMENTO, CLARISSA RODRIGUES; SILVA-DOS-SANTOS, DANIELLE; CARVALHO-PINTO, CARLA EPONINA; et al. Sheltered in Stromal Tissue Cells, Trypanosoma cruzi Orchestrates Inflammatory Neovascularization via Activation of the Mast Cell Chymase Pathway. PATHOGENS, v. 11, n. 2, p. 29-pg., . (18/14221-2, 14/50889-7)
FEIJOO, RAUL A.; BLANCO, PABLO J.; NETO, EDUARDO A. DE SOUZA A.; SANCHEZ, PABLO J.. Novel multiscale models in a multicontinuum approach to divide and conquer strategies. COMPUTATIONAL & APPLIED MATHEMATICS, v. 42, n. 4, p. 39-pg., . (18/14221-2, 14/50889-7)