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Prevalence of sarcopenia in cirrhotic patients with abdominal hernia

Grant number: 18/10430-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2019
Effective date (End): December 31, 2019
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Alberto Luiz Monteiro Meyer
Grantee:Diego Ramos Martines
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Hepatic cirrhosis (HC) is a major global health condition and persists among the ten leading causes of death in developed countries, with 38,170 deaths attributable to cirrhosis in the United States in 2014. A Brazilian study diagnosed malnutrition in 75% of patients with advanced liver disease, with a prevalence of 46% among patients classified as Child-Pugh A, 84% in the Child-Pugh B group and 95% in the Child-Pugh C group. Poor nutritional status in CH is a known factor associated with worse prognosis and higher incidence of complications. The concept of sarcopenia differs from that of malnutrition, although there is considerable overlap between the two. The prevalence of sarcopenia increases with age and approaches 5-13% during the sixth and seventh decade of life. This syndrome is associated with an increased risk of comorbidities, immobility, worsening of quality of life and mortality. Patients with HC and ascites may present peritoneal distension, and often develop hernias in weaker areas of the abdominal wall. Due to the frequent concomitant presence of sarcopenia, malnutrition and abdominal hernias in cirrhotic patients, our hypothesis is that the presence of sarcopenia may correlate with a higher prevalence of abdominal hernias in this group of patients.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PIPEK, LEONARDO ZUMERKORN; BAPTISTA, CARLOS GUILHERME; VIDIGAL NASCIMENTO, RAFAELA FARIAS; TABA, JOAO VICTOR; SUZUKI, MILENA OLIVEIRA; DO NASCIMENTO, FERNANDA SAYURI; MARTINES, DIEGO RAMOS; NII, FERNANDA; IUAMOTO, LEANDRO RYUCHI; CARNEIRO-D'ALBUQUERQUE, LUIZ AUGUSTO; MEYER, ALBERTO; ANDRAUS, WELLINGTON. The impact of properly diagnosed sarcopenia on postoperative outcomes after gastrointestinal surgery: A systematic review and meta-analysis. PLoS One, v. 15, n. 8 AUG 21 2020. Web of Science Citations: 0.

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