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In situ immune response in human disseminated chronic dermatophytosis: participation of c type lectin receptors

Grant number: 18/24175-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2019
Effective date (End): December 31, 2020
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Maria da Gloria Sousa Stafocker
Grantee:Ana Paula Carvalho dos Reis
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:16/16369-1 - Chronic disseminated dermatophytosis due to Trichophyton rubrum: role of neutrophils in the effector mechanisms and in the modulation of the adaptive response of the human infection, AP.JP


Dermatophytes are fungi that cause benign lesions in keratinized tissues of the skin, hair and nails. Trichophyton rubrum is the main species, being able to suppress and evade the immune response of the host. It is not yet known which pattern recognition receptors (PRRs) are involved in the recognition of T. rubrum. Within the PRRs family, the type C lectin receptors (CLRs) play a central role in the recognition and development of the immune response to fungi, in part through the activation of intracellular signaling pathways that induce the expression of cytokines that may polarize to a protective response or not. It is our proposal to evaluate the participation of CLRs in the lesions of patients with chronic widespread dermatophytosis (CWD) caused by T. rubrum. The understanding of these cellular pathways involved in the fungus-host interaction may provide useful information for the selection of new therapeutic targets and the development of new drugs for a better therapeutic approach not only for patients with CWD, since many of these patients present an insufficient response (recurrences) to currently available antifungal therapy, as well as to other invasive and non-invasive fungal infections.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CELESTRINO, GIOVANNA AZEVEDO; CARVALHO REIS, ANA PAULA; CRIADO, PAULO RICARDO; BENARD, GIL; TEIXEIRA SOUSA, MARIA GLORIA. Trichophyton rubrum Elicits Phagocytic and Pro-inflammatory Responses in Human Monocytes Through Toll-Like Receptor 2. FRONTIERS IN MICROBIOLOGY, v. 10, NOV 21 2019. Web of Science Citations: 0.
ANA PAULA CARVALHO REIS; FRANCIELE FERNANDES CORREIA; THAIS MARTINS JESUS; CARLA PAGLIARI; NEUSA Y SAKAI-VALENTE; WALTER BELDA JÚNIOR; PAULO RICARDO CRIADO; GIL BENARD; MARIA GLORIA TEIXEIRA SOUSA. In situ immune response in human dermatophytosis: possible role of Langerhans cells (CD1a+) as a risk factor for dermatophyte infection. Revista do Instituto de Medicina Tropical de São Paulo, v. 61, p. -, 2019. Web of Science Citations: 0.

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