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Pre-clinical evaluation of the melatonin effects on the development in ascitic Ehrlich's Tumor

Grant number: 18/19301-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2019
Effective date (End): January 31, 2020
Field of knowledge:Health Sciences - Medicine
Principal researcher:Fernando Luiz Affonso Fonseca
Grantee:Ivan Pereira Lopes
Home Institution: Centro Universitário Saúde ABC. Fundação do ABC. Santo André , SP, Brazil

Abstract

Ehrlich's tumor, a transplantable neoplasm of species-specific malignant epithelial origin, will be applied as an experimental model in order to evaluate the melatonin effects in Balb/c mice. The results will be evaluated through a new application therapy perspective, inferred from the treatment of the ascitic Ehrlich's tumor, as well as the study of the cellularity of lymphoid organs, and the evaluation of the nitric oxide produced by the macrophages of the tumor-bearing animals.