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Investigation of pre-conditioning and post-operative photobiomodulation therapy (PBMT) for knee arthroplasty (ka)

Grant number: 19/01301-0
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): June 01, 2019
Effective date (End): September 30, 2019
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Ana Claudia Muniz Renno
Grantee:Patrícia Gabrielli Vassão Alves Arakaki
Supervisor: Eeva-Liisa Laakso
Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
Research place: Mater Research, Australia  
Associated to the scholarship:16/08503-0 - Phototherapy and physical exercise program in patients with knee osteoarthritis: a triple blind randomized controlled trial., BP.DR


Osteoarthritis (OA) is the leading cause of pain and disability among older Australians and the third leading cause of life years lost to disability. Up to 20,000 knee replacements (knee arthroplasty; KA) are performed in Australia annually. Although KA restores knee alignment and relieves pain, significant adverse events and complications are associated with this procedure. Therapeutic interventions to aid recovery after KA include physical exercise activity but this can be hindered by persistent post-operative pain and swelling. A promising therapeutic alternative, photobiomodulation therapy (PBMT) may be feasible for reducing post-op pain and swelling and aiding recovery. The aim of this study is to determine the effectiveness of the PBMT before and after KA surgery, and before commencement of post-KA rehabilitation. The outcome measures will be evaluated before, and after the surgery, weekly for 2 weeks post-operatively, and again at 4 weeks post-operatively. The following measures will be used: numeric pain rating scale (NPRS); muscle strength; stair climb test; timed stands test; Timed Up and Go test (TUG); and 6-minute walk test (6-MWT). The PBMT intervention will be applied daily for 1 week before the surgery, and second daily for week 1 post-operatively after removal of compression bandages. The results will be submitted to statistical analysis. The files will be grouped as mean and standard deviation. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VASSAO, PATRICIA GABRIELLI; RENNO, ANA CLAUDIA; SMITH, BJORN N.; BENNETT, GREGORY B.; MURPHY, MICHAEL; LIEBERT, ANN; CHOW, ROBERTA; LAAKSO, E-LIISA. Pre-Conditioning and Post-Operative Photobiomodulation Therapy by a Novel Light Patch System for Knee Arthroplasty: A Protocol for a Phase 1 Study. PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY, v. 38, n. 4, . (19/01301-0)

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