Use of APC Subunits to study the regulation of small molecules in the cell cycle

• Grant number: 19/00088-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2019
• End date: January 31, 2020
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Agreement: Max Planck Society for the Advancement of Science
• Principal Investigator: Nubia Barbosa Eloy
• Grantee: Giovanna Araujo Boaventura
• Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
• Associated research grant: 17/10333-8 - APC as an entry point to study small molecule regulation of the cell cycle, AP.JP

Abstract

The anaphase promoting complex (APC) is a multiprotein complex - an E3 ubiquitin ligase - involved in the ubiquitin-dependent proteolysis of cell cycle regulatory proteins, and in which we include the destruction of mitotic cyclins during the transition from metaphase to anaphase. Identification of the complete gene set encoding the APC subunits in Arabidopsis suggests that the basic processes controlled by ubiquitin-mediated proteolysis in plants are similar to those of other organisms. However, results from several groups indicate that APC has other specific functions during plant development regulation.