Lipid profile evaluation of obese and depressed patients submitted to the hypocaloric diet rich in omega 3

• Grant number: 18/25130-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2019
• End date: February 28, 2021
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Nágila Raquel Teixeira Damasceno
• Grantee: Paula Regina Gonçalves Pereira
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 14/50983-3 - INCT 2014: complex fluids, AP.TEM

Abstract

Obesity and depression are now considered public health problems, with an increasing number of cases and important risk factors for the development of cardiovascular diseases, which is now the main cause of death among CNCDs. An analogy has been found between the negative effects that affect the metabolic and neurological system, in addition to that, many cases of depression and obesity coexist, indicating an interrelationship between these two diseases. Studies have shown that hyperlipidic diets can improve brain functions by being a potential alternative to treat mood disorders and an important ally in weight reduction programs. Polyunsaturated fatty acids (PUFAs) omega 3 have anti-inflammatory and cardioprotective action, being important energy fuel for the brain and, potentially, play a relevant role in the prevention and management of depression and CVD. This study proposes to evaluate the impact of the hyperlipidic diet rich in omega 3 in the clinical profile and in the cardiometabolic risk of patients with depression and obesity. It will be a controlled clinical trial with 3-month follow-up performed with three groups, one group will receive a high-fat diet rich in omega 3, another will receive a balanced diet and the third group will not undergo dietary intervention. All three groups will receive drug intervention. During the study, demographic parameters, clinical profile, lipid profile, LDL and HDL size, and ketone bodies will be analyzed. Statistical analyzes will be performed by the SPSS program.