Evaluation of the compound [Ru3O(CH3COO)6(4-ampy) 3]CH3COO as a potential candidate for metallopharmaceutical

• Grant number: 19/04173-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2019
• End date: January 31, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Sofia Nikolaou
• Grantee: Bruno Faria Abrantes Pinheiro
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The project aims to synthesize and purify the [Ru3O (CH3COO) 6 (4-ampy) 3] CH3COO complex and to study the interactions of the symmetric ruthenium trinuclear complex containing three 4-aminopyridine ligands with DNA and HSA (human serum albumin), the from spectrophotometric titration and luminescence suppression experiments, respectively. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SARMENTO, CAROLINE O.; PINHEIRO, BRUNO F. A.; ABRAHAO, JOSIELLE; CHAVES, OTAVIO A.; MOREIRA, MARIETE B.; NIKOLAOU, SOFIA. Interactions of a Ruthenium-Ketoprofen Compound with Human Serum Albumin and DNA: Insights from Spectrophotometric Titrations and Molecular Docking Calculations. CHEMISTRYSELECT, v. 7, n. 4, JAN 27 2022. (18/18060-3, 19/04173-3)