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Effects of maternal and paternal intake of high fat and high sugar diet on male reproductive programming of offspring in early adulthood

Grant number: 18/17412-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2019
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Luciana Pellegrini Pisani
Grantee:Marcela Nascimento Sertorio
Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
Associated scholarship(s):22/05377-4 - Programmed molecular mechanisms in insulin sensitivity associated with changes in expression of miRNAs in adipocytes from male and female offspring by maternal diet-induced obesity, BE.EP.DR


Inadequate maternal nutrition as well as the paternal nutrition, can have an impact on the health of future generations. Obesity is capable of activating a systemic inflammatory response that alters the quality of parental gametes, the uterine environment and breast milk, programming the pattern of health and disease throughout the life of the offspring. Studies indicate that obese mothers or fathers can alter the quality of the gametes in the offspring, and that eating a diet rich in simple carbohydrates and lipids can perpetuate its consequences for the next generation. Therefore, we will evaluate the effects of maternal and paternal intake of high fat and high sugar diet, in the programming of reproductive inflammatory response in male offspring and its reproductive parameters in early adult life. In the male offspring at 90 days, we will evaluate the relative weight of testis, epididymis, prostate and seminal vesicle; serum content of testosterone, LH and FSH; testicular and epididymal content of the cytokines TNF-±, IL1 and IL-6; expression of TLR4 receptor and the transcription factor NFºB in the testis and epididymis; testicular content of key enzymes in the production of testosterone StAR and 17²-HSD; testicular content of the tight junction ZO-1; testicular and epididymal antioxidant activity of the enzymes SOD, CAT and GST; testicular and epididymal concentration of markers for oxidative stress MDA and carbonyl proteins; daily sperm production, sperm count, epididymal transit time, and sperm morphology. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SERTORIO, MARCELA NASCIMENTO; ESTADELLA, DEBORA; RIBEIRO, DANIEL ARAKI; PISANI, LUCIANA PELLEGRINI. Could parental high-fat intake program the reproductive health of male offspring? A review. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, . (19/09724-8, 18/17412-3)

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