Suppression effect of otoacoustic emissions evoked by transient stimulus in individuals with Neurofibromatosis type 1

• Grant number: 18/21550-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2019
• End date: December 31, 2019
• Field of knowledge: Health Sciences - Speech Therapy
• Principal Investigator: Daniela Gil
• Grantee: Nathalia Seppe Fernandes
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Introduction: Neurofibromatosis type 1 is an autosomal dominant, progressive genetic disease with an incidence of 1/3,000 live births, which affects people from different parts of the world in all races without distinction as to sex. Studies indicate that the auditory system of these individuals may be affected due to the presence of neurofibromas installed in the external acoustic meatus, in addition to findings compatible with possible cochlear dysfunctions. Objective: to investigate the occurrence of the suppression effect of otoacoustic emissions evoked by transient stimulus in individuals with Neurofibromatosis type 1.Methodology: Individuals with type 1 neurofibromatosis will be selected, regardless of gender, and aged between 9 and 35 years. All subjects will be submitted to basic audiological evaluation (audiometry, immitance and contralateral acoustic reflexes) and specific evaluation (suppression effect of otacoustic emissions), in which the objective of the study is guided.