Vasohibin (vash) as possible marker of carcinogenesis in colorectal adenocarcinoma

• Grant number: 18/21906-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2019
• End date: December 31, 2020
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Denise Gonçalves Priolli
• Grantee: Maycon Giovani Santana
• Host Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil

Abstract

According to the World Health Organization, cancer is ranked as the second leading cause of death in the world, behind the diseases that affect the circulatory system. In Brazil, excluding non-melanoma skin cancer, colorectal cancer is the third most common in men and the second in women. Carcinogenesis is dependent on a sort of factor. It is described in three stages: initiation, promotion, and progression. The tumor progression requires the angiogenic process sufficient to its metabolic demand. The angiogenesis modulator, vasohibin is a functional protein that has an antiangiogenic activity, regulates the endothelial growth and proliferation mechanisms of tumor growth inhibition. However, this molecule is still not studied as a colorectal carcinogenesis biomarker. For this study samples of healthy tissue, polyps adenomatous and adenocarcinoma colorectal will be submitted to the histology, microvessel counts, and immunohistochemical analysis using the antibody anti-VASH in order to analyze VASH and its action on vascular density in the different carcinogenesis stages. It is intended to determine the value of VASH as the diagnostic biomarker and/or prognosis in colorectal cancer.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PELOSI, ANDREA; FERNANDES, ANNA MARIA A. P. C.; MACIEL, LEONARDO; SILVA, ALEX A. R.; MENDES, GIULIA F.; BUENO, LUISA F. G.; SILVA, LIVIA MARIA F. M.; BREDARIOL, RAFAEL G.; SANTANA, MAYCON; PORCARI, ANDREIA; et al. Liquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model. PLoS One, v. 17, n. 9, p. 8-pg., 2022-09-21. (19/04314-6, 18/21471-5, 19/23592-7, 18/21906-1)