Advanced search
Start date
Betweenand

Effects of miR-29c on skeletal muscle plasticity: implications for the control of muscle mass

Grant number: 19/08996-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2019
Effective date (End): May 31, 2020
Field of knowledge:Biological Sciences - Biology
Principal researcher:Anselmo Sigari Moriscot
Grantee:William Jose da Silva
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:15/04090-0 - Identification and caracterization of mechanisms involved in skeletal muscle mass control and regeneration, AP.TEM

Abstract

Good health and quality of life are closely related to the good performance of skeletal muscle tissue functions. For this, it is essential that the muscle can efficiently activate the processes that regulate the growth, regeneration, metabolism and adaptation of the mass in front of the demands of the environment. Under this latter aspect, muscle mass is mainly determined by the balance between synthesis and degradation of proteins. Several conditions lead to increased protein degradation, causing a reduction in mass and consequently inefficiency of muscle function (Atrophy), among which we can mention physiological states such as physical inactivity and aging, immobilization of fractured limbs, malnutrition and microgravity, in addition to pathological conditions such as the peripheral nerve section, sepsis, chronic treatment with corticosteroids, renal failure, AIDS and cancer-induced cachexia. For years our research group has been dedicated to elucidating mechanisms and identifying elements that can regulate skeletal muscle plasticity. During the development of subproject 3, we identified miR-29c as a potential hypertrophic agent, as well as inducing an increase in muscle mass and function, reducing expression and targeting MuRF1, one of the most expressed atrogenes in most atrophic conditions cited above. This postdoctoral project will proceed to subproject 3, further exploring the effects of hyperexpression of miR-29c on the effects on muscle metabolism and the mechanisms that lead to muscle hypertrophy, and these results have stimulated us to challenge the effects of miR-29c on some of these atrophic conditions, such as during food deprivation, denervation, immobilization, dexamethasone treatment and cancer-induced cachexia.

Articles published in other media outlets (13 total):
More itemsLess items
G1: Cientista brasileiro pesquisa terapia genética para ganhar massa muscular (10/Sep/2019)
O Sul: Um cientista brasileiro pesquisa terapia genética para ganhar massa muscular (12/Sep/2019)
O Sul online: Um cientista brasileiro pesquisa terapia genética para ganhar massa muscular (11/Sep/2019)
Jornal Tijucas: Cientista brasileiro pesquisa terapia genética para ganhar massa muscular (10/Sep/2019)
Notícia Plus: Cientista brasileiro pesquisa terapia genética para ganhar massa muscular (10/Sep/2019)
Portal G1 News: Cientista brasileiro pesquisa terapia genética para ganhar massa muscular (10/Sep/2019)
Ideal MT: Cientista brasileiro pesquisa terapia genética para ganhar massa muscular (10/Sep/2019)
Notivagos: Cientista brasileiro pesquisa terapia genética para ganhar massa muscular (10/Sep/2019)
Só Fatos: Cientista brasileiro pesquisa terapia genética para ganhar massa muscular (10/Sep/2019)
Resende News: Cientista brasileiro pesquisa terapia genética para ganhar massa muscular (10/Sep/2019)
Portal da Enfermagem: Cientista brasileiro pesquisa terapia genética para ganhar massa muscular (10/Sep/2019)
Cultura FM 87,9: Cientista brasileiro pesquisa terapia genética para ganhar massa muscular (10/Sep/2019)
Silvani Notícias (G1 Notícias): Cientista brasileiro pesquisa terapia genética para ganhar massa muscular (10/Sep/2019)