Efect of chronic restraint stress on rats performance in a spatial learning task

• Grant number: 19/03384-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: June 01, 2019
• End date: February 28, 2021
• Field of knowledge: Humanities - Psychology - Experimental Psychology
• Principal Investigator: Andréia Schmidt
• Grantee: Vítor Pansarim
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Exposure to chronic stressors has been used as animal model for the study of depression, once, since it has been shown to cause anhedonia. In addition, chronic stress has been shown to be effective in altering the performance of rats in acquisition and retention tasks. Most studies using chronic stress lasting for 21 days or more have observed an impairment on animal performance. However, some research that exposed rats to reduced periods of chronic stress found na improvement on performance. Although most research has used males, there are studies demonstrating that chronic stress can have distinct effects on the performance of males and females. The presente study aims to investigate the effect of duration of chronic restraint stress (CRS) on the performance of male and female rats in a spatial learning task. It will be used 48 Sprague-Dawley rats, (24 males and 24 females), composing six groups of eight subjects: male long stress group and female long stress group (22 days exposure to CRS), male short stress group and female short stress group (11 days exposure to CRS) and male control group and female control group (no exposure to CRS). During the CRS exposure period, all animals will proceed on sucrose solution preference tests. After the end of the CRS period, all subjects will proceed on two spatial learning sessions in the Morris Water Maze (MWM). The escape latency will be used as an learning measure in yhe task and will be compared between the six groups of the experiment. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PANSARIM, VITOR; LEITE-PANISSI, CHRISTIE R. A.; SCHMIDT, ANDREIA. Chronic restraint stress alters rat behavior depending on sex and duration of stress. Behavioural Processes, v. 207, p. 8-pg., 2023-03-24. (14/50909-8, 19/03384-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PANSARIM, Vítor. Effects of the chronic restraint stress duration on spatial learning and behaviors of male and female Sprague-Dawley rats. 2021. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (PCARP/BC) Ribeirão Preto.