Evaluation of the biological activity of topical formulations of budesonide in inflammatory skin models

• Grant number: 19/05100-0
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: August 01, 2019
• End date: July 31, 2020
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Daniele Ribeiro de Araujo
• Grantee: Estefânia Vangelie Ramos Campos
• Supervisor: Sarah Hedtrich
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Institution abroad: University of British Columbia, Vancouver (UBC), Canada
• Associated to the scholarship: 17/24402-1 - pH AND TEMPERATURE SENSITIVE DRUG NANOCARRIERS FOR SKIN APPLICATIONS, BP.PD

Abstract

Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder characterized by intense itching and recurrent eczematous lesions. Although the pathogenesis of this disorder is not completely understood, it appears to result from the complex interplay between defects in skin barrier function, environmental and infectious agents, and immune abnormalities. The current therapies for AD involve the use of topical corticosteroids and/or topical calcineurin inhibitors. A number of therapeutic agents are available for the treatment of AD. However, topical delivery to the skin has been a consistent challenge for researchers, because of the barrier nature of skin. The present project will explore the novel PLGA nanoparticles loading budesonide researched for AD therapy via topical route. Feasibility of this nanoformulation for AD treatment will be evaluated employing in vitro skin models emulating the AD symptoms. Through this model, the pharmacodynamics of these nanoformulations, will be elucidated through the evaluation of inflammatory cytokines, which are dysregulated in this disease. Furthermore, in this proposal it is also intended to analyze the permeation of these carrier systems fluorescently labeled on human skin. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RAMOS CAMPOS, ESTEFANIA VANGELIE; PROENCA, PATRICIA LUIZA DE FREITAS; DORETTO-SILVA, LORENA; ANDRADE-OLIVEIRA, VINICIUS; FRACETO, LEONARDO FERNANDES; DE ARAUJO, DANIELE RIBEIRO. Trends in nanoformulations for atopic dermatitis treatment. Expert Opinion on Drug Delivery, v. 17, n. 11, AUG 2020. (19/20303-4, 17/24402-1, 19/05100-0)

CAMPOS, ESTEFANIA V. R.; PROENCA, PATRICIA L. F.; DA COSTA, TAIS GERMANO; DE LIMA, RENATA; HEDTRICH, SARAH; FRACETO, LEONARDO FERNANDES; DE ARAUJO, DANIELE RIBEIRO. Hydrogels Containing Budesonide-Loaded Nanoparticles to Facilitate Percutaneous Absorption for Atopic Dermatitis Treatment Applications. ACS APPLIED POLYMER MATERIALS, v. 3, n. 9, p. 4436-4449, SEP 9 2021. (19/05100-0, 19/20303-4, 17/24402-1)

BABITY, SAMUEL; COUTURE, FREDERIC; CAMPOS, ESTEFANIA V. R.; HEDTRICH, SARAH; HAGEN, RAPHAEL; FEHR, DANIEL; BONMARIN, MATHIAS; BRAMBILLA, DAVIDE. A Naked Eye-Invisible Ratiometric Fluorescent Microneedle Tattoo for Real-Time Monitoring of Inflammatory Skin Conditions. ADVANCED HEALTHCARE MATERIALS, DEC 2021. (17/24402-1, 19/05100-0)

BARTOLUCCI, CECILIA; ANTONACCI, AMINA; ARDUINI, FABIANA; MOSCONE, DANILA; FRACETO, LEONARDO; CAMPOS, ESTEFANIA; ATTAALLAH, RAOUIA; AMINE, AZIZ; ZANARDI, CHIARA; CUBILLANA-AGUILERA, LAURA M.; et al. Green nanomaterials fostering agrifood sustainability. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 125, APR 2020. (19/05100-0, 17/21004-5, 17/24402-1)

CAMPOS, ESTEFANIA V. R.; PROENCA, PATRICIA L. F.; DA COSTA, TAIS G.; DE LIMA, RENATA; FRACETO, LEONARDO F.; DE ARAUJO, DANIELE R.. Using Chitosan-Coated Polymeric Nanoparticles-Thermosensitive Hydrogels in association with Limonene as Skin Drug Delivery Strategy. BIOMED RESEARCH INTERNATIONAL, v. 2022, p. 18-pg., 2022-04-07. (19/05100-0, 17/24402-1, 19/20303-4)

CAMPOS, ESTEFANIA V. R.; PEREIRA, ANDERSON E. S.; DE OLIVEIRA, JHONES LUIZ; CARVALHO, LUCAS BRAGANCA; GUILGER-CASAGRANDE, MARIANA; DE LIMA, RENATA; FRACETO, LEONARDO FERNANDES. How can nanotechnology help to combat COVID-19? Opportunities and urgent need. JOURNAL OF NANOBIOTECHNOLOGY, v. 18, n. 1, SEP 5 2020. (17/21004-5, 19/05100-0, 18/21142-1, 18/23608-8, 20/05816-2, 17/24402-1)