Maximizing metastatic breast cancer patient outcomes using diet and exercise

• Grant number: 19/09877-9
• Support type: Scholarships abroad - Research Internship - Doctorate (Direct)
• Effective date (Start): January 06, 2020
• Effective date (End): January 05, 2021
• Field of knowledge: Health Sciences - Nutrition - Nutritional Analysis of Population
• Principal Investigator: Alceu Afonso Jordão Junior
• Grantee: Bruna Ramos da Silva
• Supervisor abroad: Carla Prado
• Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Local de pesquisa : University of Alberta, Canada
• Associated to the scholarship: 17/07963-0 - Evaluation of the metabolic, oxidative and anthropometric profile in women with Breast Cancer, BP.DD

Abstract

Despite the major advances in the treatment of early-stage breast cancer in recent decades, metastatic breast cancer is still considered incurable due to resistance to most available treatments. In addition, the toxicity of the treatment may be quite high with metastatic regimens, which may limit the total dose received. Both diet and exercise have been shown to attenuate treatment toxicity in humans. Objective: To assess the efficacy of a combination of acute aerobic exercise and a low-carbohydrate, low-calorie diet given acutely prior to chemotherapy treatments. Methodology: 42 women with metastatic breast cancer who will receive chemotherapy. The intervention of aerobic exercises will consist of a single guarded of 30 minutes. The diet intervention consists of the provision of meals prepared in a metabolic kitchen under the supervision of a nutritionist with a caloric content equivalent to 50% of measured energy needs and 15% of carbohydrates 72 hours prior to each chemotherapy. The results of the tumors will be evaluated by magnetic resonance and venipuncture, while symptoms and quality of life will be evaluated through a questionnaire before and after up to six chemotherapy treatments of a consistent treatment protocol. (AU)