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Maximizing metastatic breast cancer patient outcomes using diet and exercise

Grant number: 19/09877-9
Support Opportunities:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): January 06, 2020
Effective date (End): January 05, 2021
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Principal Investigator:Alceu Afonso Jordão Junior
Grantee:Bruna Ramos da Silva
Supervisor: Carla Prado
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: University of Alberta, Canada  
Associated to the scholarship:17/07963-0 - Evaluation of the metabolic, oxidative and anthropometric profile in women with Breast Cancer, BP.DD


Despite the major advances in the treatment of early-stage breast cancer in recent decades, metastatic breast cancer is still considered incurable due to resistance to most available treatments. In addition, the toxicity of the treatment may be quite high with metastatic regimens, which may limit the total dose received. Both diet and exercise have been shown to attenuate treatment toxicity in humans. Objective: To assess the efficacy of a combination of acute aerobic exercise and a low-carbohydrate, low-calorie diet given acutely prior to chemotherapy treatments. Methodology: 42 women with metastatic breast cancer who will receive chemotherapy. The intervention of aerobic exercises will consist of a single guarded of 30 minutes. The diet intervention consists of the provision of meals prepared in a metabolic kitchen under the supervision of a nutritionist with a caloric content equivalent to 50% of measured energy needs and 15% of carbohydrates 72 hours prior to each chemotherapy. The results of the tumors will be evaluated by magnetic resonance and venipuncture, while symptoms and quality of life will be evaluated through a questionnaire before and after up to six chemotherapy treatments of a consistent treatment protocol. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, BRUNA RAMOS; RUFATO, SARAH; MIALICH, MIRELE S.; CRUZ, LORIS P.; GOZZO, THAIS; JORDAO, ALCEU A.. An Evaluation of Metabolic, Dietetic, and Nutritional Status Reveals Impaired Nutritional Outcomes in Breast Cancer Patients. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, v. 74, n. 10, p. 12-pg., . (17/07963-0, 19/09877-9)
DA SILVA, BRUNA RAMOS; RUFATO, SARAH; MIALICH, MIRELE S.; CRUZ, LORIS P.; GOZZO, THAIS; JORDAO, ALCEU A.. Metabolic syndrome and unfavorable outcomes on body composition and in visceral adiposities indexes among early breast cancer women post-chemotherapy. CLINICAL NUTRITION ESPEN, v. 44, p. 306-315, . (19/09877-9, 17/07963-0)
DA SILVA, BRUNA R.; RUFATO, SARAH; MIALICH, MIRELE S.; CRUZ, LORIS P.; GOZZO, THAIS; JORDAO, ALCEU A.. Phase angle is related to oxidative stress and antioxidant biomarkers in breast cancer patients undergoing chemotherapy. PLoS One, v. 18, n. 6, p. 15-pg., . (17/07963-0, 19/09877-9)

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